A nurse is caring for a client who is scheduled to undergo a thoracentesis. Which intervention would the nurse complete prior to the procedure? The nurse assesses the client after a thoracentesis. Which assessment finding warrants immediate action? You should have 2 responses for this question: 1 for Intervention and 1 for Assessment.

Choice A Reason: Increased Serum Albumin

Increased serum albumin is not a direct indicator of the therapeutic effect of lactulose in patients with chronic hepatitis. Albumin is a protein made by the liver, and its levels can be affected by liver function. However, lactulose primarily works by reducing ammonia levels in the blood, not by increasing albumin levels. Normal serum albumin levels range from 3.5 to 5.5 grams per deciliter (g/dL). While improved liver function might eventually lead to increased albumin levels, this is not the primary therapeutic effect of lactulose.

Choice B Reason: Decreased Serum Bilirubin

Decreased serum bilirubin is also not a direct indicator of lactulose’s therapeutic effect. Bilirubin is a byproduct of the normal breakdown of red blood cells and is processed by the liver. Elevated bilirubin levels can indicate liver dysfunction, but lactulose’s main role is to reduce ammonia levels, not bilirubin. Normal serum bilirubin levels are typically between 0.1 to 1.2 milligrams per deciliter (mg/dL). While improved liver function might reduce bilirubin levels, this is not the primary goal of lactulose therapy.

Choice C Reason: Decreased Serum Ammonia

Decreased serum ammonia is the correct indicator of the therapeutic effect of lactulose in patients with chronic hepatitis. Lactulose is used to treat hepatic encephalopathy, a condition caused by high levels of ammonia in the blood due to liver dysfunction. Lactulose works by converting ammonia into ammonium, which is then excreted from the body. Normal serum ammonia levels are less than 50 micromoles per liter (µmol/L) in adults56. A decrease in serum ammonia levels indicates that lactulose is effectively reducing the toxic levels of ammonia in the blood, thereby achieving its desired therapeutic effect.

Choice D Reason: Decreased Serum Alanine Aminotransferase (ALT)

Decreased serum alanine aminotransferase (ALT) is not a direct indicator of lactulose’s therapeutic effect. ALT is an enzyme found in the liver that helps convert proteins into energy for liver cells. Elevated ALT levels can indicate liver damage. Normal ALT levels range from 7 to 56 units per liter (U/L). While improved liver function might reduce ALT levels, lactulose’s primary role is to reduce ammonia levels, not directly affect ALT.

Choice A Reason:

0.45% sodium chloride (half-normal saline) is an appropriate solution for treating hypernatremia, especially in a client who is NPO (nothing by mouth). This hypotonic solution helps to gradually reduce the serum sodium levels by providing free water to the extracellular space, which dilutes the high sodium concentration. It is essential to administer this solution slowly to avoid rapid shifts in fluid balance, which can lead to cerebral edema.

Choice B Reason:

Dextrose 5% in 0.9% sodium chloride (D5NS) is not the best choice for treating hypernatremia. While it provides some free water, the presence of 0.9% sodium chloride makes it an isotonic solution, which does not effectively lower serum sodium levels. This solution is more suitable for maintaining fluid balance rather than correcting hypernatremia.

Choice C Reason:

Lactated Ringer’s is also not appropriate for treating hypernatremia. This isotonic solution contains electrolytes, including sodium, which can exacerbate hypernatremia rather than correct it. Lactated Ringer’s is typically used for fluid resuscitation and electrolyte replacement in other clinical scenarios.

Choice D Reason:

Dextrose 10% in water (D10W) is a hypertonic solution and is not suitable for treating hypernatremia. While it provides free water, the high concentration of dextrose can lead to rapid shifts in fluid balance and potential complications such as hyperglycemia. This solution is generally used for providing calories and preventing hypoglycemia in specific clinical situations.