Patients taking which cholesterol-lowering agent may require supplements of fat-soluble vitamins A, D, E, and K?

According to the World Health Organization (WHO), noncommunicable diseases (NCDs) are the leading cause of death globally, accounting for 74% of all deaths. NCDs are chronic diseases that are not transmitted from person to person, such as cardiovascular diseases, cancers, chronic respiratory diseases and diabetes.The main risk factors for NCDs are modifiable behaviours, such as tobacco use, physical inactivity, unhealthy diet and the harmful use of alcohol.These behaviours can lead to metabolic risk factors, such as raised blood pressure, increased blood glucose, elevated blood lipids and obesity, which in turn increase the risk of developing NCDs. Therefore, lifestyle changes that reduce these risk factors can prevent or delay many NCDs and improve health outcomes.

Choice A is wrong because trauma is not a major contributing factor to many diseases.Trauma is an injury or damage to living tissue caused by an external force, such as accidents, violence or natural disasters.Trauma can result in acute or chronic conditions, such as infections, fractures, burns, bleeding or organ failure.

However, trauma is not a common cause of NCDs, which are the main burden of disease globally.

Choice C is wrong because congenital factors are not the greatest contributing factor to many diseases.Congenital factors are those that are present at birth, such as genetic disorders, birth defects or inherited diseases.Congenital factors can affect the development and function of various organs and systems in the body, leading to various health problems.

However, congenital factors are not the main cause of NCDs, which are largely influenced by environmental and behavioural factors.

Choice D is wrong because genetics is not the greatest contributing factor to many diseases.

Genetics is the study of how traits are inherited and expressed in living organisms.

Genetics can influence the susceptibility and resistance to various diseases, as well as the response to treatment and prevention strategies.

However, genetics is not the sole determinant of health and disease, as environmental and behavioural factors also play a significant role in modulating gene expression and function.

Diuretics are medicines that help the kidneys get rid of excess water and salt, which can ease the symptoms of heart failure, such as breathlessness and swelling.However, diuretics may also lower the blood pressure by reducing the blood volume and the cardiac output. This can cause symptoms such as dizziness, fatigue, or fainting.Hypotension is defined as a systolic blood pressure lower than 90 mmHg or a diastolic blood pressure lower than 60 mmHg.

Choice A is wrong because fluid retention is the opposite of what diuretics do. Diuretics increase the urine output and decrease the fluid accumulation in the body.

Choice C is wrong because hyperglycemia is not a common side effect of diuretics. Hyperglycemia is a condition where the blood sugar level is too high.Diuretics may affect the blood sugar level in some cases, but usually not significantly.

Choice D is wrong because diarrhea is not a typical side effect of diuretics.

Diarrhea is a condition where the stool is loose and watery.Diuretics may cause some gastrointestinal discomfort, such as nausea or cramps, but not diarrhea.

Normal ranges for blood pressure are 120/80 mmHg for systolic/diastolic in healthy adults, and 140/90 mmHg or higher for hypertension.Normal ranges for blood sugar are 70-100 mg/dL for fasting glucose, and less than 140 mg/dL for postprandial glucose.