Patients with aminoglycoside therapy should be monitored for:

A. "Tetracycline inhibits protein synthesis."
Tetracycline inhibits bacterial protein synthesis by binding to the bacterial ribosomes, which are crucial for making proteins. This disruption in protein synthesis prevents bacterial growth and replication.

B. "Tetracycline blocks RNA synthesis."
Tetracycline primarily affects protein synthesis, not RNA synthesis. It binds to the 30S subunit of the bacterial ribosome and disrupts the translation process.

C. "Tetracycline degrades the bacterial cell wall."
Tetracycline does not target the bacterial cell wall. Drugs like penicillin and cephalosporins work by disrupting cell wall synthesis, but tetracycline operates differently by inhibiting protein synthesis.

D. "Tetracycline binds to magnesium ions."
Tetracycline does not specifically bind to magnesium ions. Its primary mode of action involves binding to the bacterial ribosome, as mentioned in the first correct statement.

A. Ototoxicity and Nephrotoxicity:
Ototoxicity: Aminoglycosides can damage the inner ear structures, leading to hearing loss and balance issues.
Nephrotoxicity: These drugs can harm the kidneys, potentially causing acute kidney injury or chronic kidney disease. Monitoring kidney function is crucial to prevent renal damage.

B. Ototoxicity and Cardiotoxicity:
Ototoxicity: As mentioned above, aminoglycosides can damage the inner ear, affecting hearing and balance.
Cardiotoxicity: Aminoglycosides primarily affect the ears and kidneys; they do not directly target the heart. Cardiotoxicity is not a common side effect associated with aminoglycosides.

C. Hepatotoxicity and Nephrotoxicity:
Hepatotoxicity: This term refers to liver damage caused by drugs or toxins. Aminoglycosides are not known to cause liver problems; their primary concern is kidney damage.
Nephrotoxicity: As mentioned earlier, aminoglycosides can harm the kidneys, which is a well-known side effect.

D. Cardiotoxicity and Hepatotoxicity:
Cardiotoxicity: This term refers to the toxic effects on the heart, leading to various heart-related issues. Aminoglycosides do not primarily affect the heart; their main concerns are the ears (ototoxicity) and kidneys (nephrotoxicity).
Hepatotoxicity: Aminoglycosides are not typically associated with liver damage. They are primarily metabolized and excreted by the kidneys, which is why kidney monitoring is crucial during their use.