Prompt management of hypothyroidism in infancy is necessary because:

Choice A reason:

Facial edema is a common clinical manifestation of nephrotic syndrome in children. This occurs due to the retention of fluid in the tissues, which is a result of the kidneys leaking protein into the urine (proteinuria). The loss of protein reduces the oncotic pressure in the blood vessels, leading to fluid accumulation in the interstitial spaces, particularly noticeable around the eyes and face.

Choice B Reason:

Cloudy smoky brown-colored urine is not typically associated with nephrotic syndrome. This symptom is more indicative of hematuria, which is the presence of blood in the urine. Hematuria is more commonly seen in conditions such as glomerulonephritis rather than nephrotic syndrome.

Choice C Reason:

Weight loss is not a characteristic symptom of nephrotic syndrome. In fact, children with nephrotic syndrome often experience weight gain due to fluid retention. The accumulation of fluid in the body can lead to an increase in weight, rather than a loss.

Choice D Reason:

Frothy appearing urine is a hallmark sign of nephrotic syndrome. The frothiness is due to the high levels of protein being excreted in the urine (proteinuria). When protein is present in the urine, it can cause the urine to appear foamy or frothy.

Choice A reason:

Extracellular hyperglycemia refers to high blood sugar levels outside the cells. While hyperglycemia is a common feature of diabetic ketoacidosis (DKA), it is not the direct cause of the condition. DKA occurs when the body cannot use glucose for energy due to a lack of insulin, leading to the breakdown of fat and protein for energy, which produces ketones and causes acidosis.

Choice B Reason:

Hypoglycemia, or low blood sugar, is not associated with diabetic ketoacidosis. In fact, DKA is characterized by high blood sugar levels. Hypoglycemia is a separate condition that can occur in individuals with diabetes, particularly if they take too much insulin or skip meals.

Choice C Reason:

The use of fat and protein as an energy source is the primary mechanism behind diabetic ketoacidosis. When insulin is deficient, the body cannot utilize glucose for energy. As a result, it breaks down fat and protein to produce energy. This process generates ketones, which are acidic and lead to the development of ketoacidosis.

Choice D Reason:

Increased cellular metabolism of glucose is not related to diabetic ketoacidosis. In DKA, the problem is that cells cannot use glucose effectively due to a lack of insulin. Instead, the body resorts to breaking down fat and protein for energy, leading to the production of ketones and acidosis.