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The client receives one dose of 200 mg of a medication. How much drug is in the body at 3 half-lives?

100

Answer and Explanation

The Correct Answer is C

Here’s the step-by-step process:

After the first half-life (1 half-life), 50% of the initial drug is left.

200 mg → 100 mg (half is eliminated, 100 mg remains).

After the second half-life (2 half-lives), 50% of the remaining drug is eliminated again.

100 mg → 50 mg (half of 100 mg is eliminated, 50 mg remains).

After the third half-life (3 half-lives), 50% of the remaining drug is eliminated again.

50 mg → 25 mg (half of 50 mg is eliminated, 25 mg remains).

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Correct Answer is ["4"]

Explanation

Convert micrograms (mcg) to milligrams (mg):

The prescribed dose is 200 mcg.

We know that 1 mg = 1000 mcg.

Therefore, 200 mcg = 200 / 1000 = 0.2 mg.

Calculate the number of tablets:

Each tablet contains 0.05 mg of levothyroxine.

The desired dose is 0.2 mg.

We can use the following formula: (Desired dose) / (Tablet strength) = Number of tablets

(0.2 mg) / (0.05 mg/tablet) = 4 tablets

A. The stomach acid has a lower pH level which results in increase absorption B. The glomerular filtration rate (GFR) is increased causing rapid excretion C. The liver enzyme system responsible for drug metabolism is not fully developed D. The albumin levels are elevated due to rapid growth and protein binding is enhanced

Correct Answer is C

Explanation

A) The stomach acid has a lower pH level which results in increased absorption: While it is true that neonates have a lower gastric pH, which could affect the absorption of certain medications, this factor does not directly increase the risk for drug toxicity. Lower pH may increase absorption for some drugs, but it is not as critical in neonates as the immaturity of other organs, such as the liver and kidneys, which are responsible for drug metabolism and excretion.

B) The glomerular filtration rate (GFR) is increased causing rapid excretion: In neonates, the glomerular filtration rate (GFR) is actually decreased, not increased. This leads to slower excretion of medications, which can increase the risk for drug toxicity, especially for drugs that rely on renal elimination. This decreased renal function can result in accumulation of the drug in the bloodstream, potentially leading to toxicity.

C) The liver enzyme system responsible for drug metabolism is not fully developed: The liver enzyme system in neonates is immature, which significantly impacts the metabolism of drugs. Enzymatic activity is critical for breaking down medications to their active or inactive forms. Due to the underdeveloped liver function, drugs may not be metabolized properly, leading to a longer half-life and an increased risk for drug toxicity. This is a key factor in the increased risk of toxicity in neonatal clients.

D) The albumin levels are elevated due to rapid growth and protein binding is enhanced: Neonates typically have lower albumin levels, not elevated levels. Albumin is crucial for binding medications, and lower levels in neonates can result in more free (unbound) drug circulating in the bloodstream, which can increase the risk of drug toxicity. Elevated albumin would theoretically reduce this risk, but this is not typically the case in neonates.

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Laboratory Test	Result	Normal Range
Sodium	146 mEq/dL	135-145 mEq/L
Calcium	8.2 mg/dL	8.4-10.2 mg/dL
Magnesium	1.2 mg/dL	1.6-2.2 mg/dL
Gastric pH	6	1-4

The client receives one dose of 200 mg of a medication. How much drug is in the body at 3 half-lives?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A client is prescribed levothyroxine 200 mcg PO daily before breakfast. In the medication room are tablets labelled 0.05 mg/tablet. How many tablet(s) will you administer to the client? Fill in the blank with a numeric value. Answer to the nearest whole tablet

Correct Answer is ["4"]

Explanation

The nurse is administering a prescribed medication to neonatal client. Which factor is most likely to increase the risk for drug toxicity in this client?

Correct Answer is C

Explanation

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