The nurse assisting with Phase 1 drug studies is talking with a woman who asks, "Why can't I participate in this study?" What would be the nurse's best response?
Women are more prone to adverse effects from medications.
Drugs pose a greater risk to women of reproductive age.
Drugs affect women differently than they affect men.
Drugs are tested only on men because they are stronger.
The Correct Answer is B
Choice A rationale
It is not correct to say that women are more prone to adverse effects from medications than men. Adverse effects can vary based on individual responses, and gender is not the sole determinant.
Choice B rationale
Women of reproductive age are often excluded from early-phase drug trials due to the potential risks that experimental drugs could pose to developing fetuses. The reproductive risk needs to be carefully managed to avoid harm.
Choice C rationale
While it is true that drugs can affect women differently than men, this answer does not directly address the specific reason why women are excluded from Phase 1 studies, which is primarily due to the potential risks to reproductive health.
Choice D rationale
This is incorrect because drugs are not tested only on men because they are stronger. This statement is not scientifically accurate and does not reflect the principles of clinical trial design.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A rationale
CSF analysis and MRI are crucial in diagnosing multiple sclerosis (MS). CSF may show elevated levels of oligoclonal bands, indicative of immune system activity in the central nervous system. MRI can detect lesions or plaques in the brain and spinal cord, which are characteristic of MS.
Choice B rationale
Serum albumin and CT scan are not standard diagnostic tools for MS. Serum albumin is more relevant to liver function and nutritional status, while CT scans are less sensitive than MRIs in detecting MS lesions.
Choice C rationale
CSF proteins and angiography are not standard tests for diagnosing MS. While CSF protein levels might be altered in MS, angiography is used to visualize blood vessels and is not relevant to MS diagnosis.
Choice D rationale
Serum anti-acetylcholine antibodies and x-rays are not used to diagnose MS. Anti-acetylcholine antibodies are related to myasthenia gravis, and x-rays are not useful for visualizing MS lesions.
Correct Answer is C
Explanation
Choice A rationale
Myasthenia gravis primarily affects voluntary muscles, especially those involved in breathing and facial movements. Gastrointestinal (GI) and lower extremity muscles are generally not the main muscles affected by this condition. It is an autoimmune disorder that impacts the neuromuscular junction, where nerves communicate with muscles, leading to muscle weakness and fatigue.
Choice B rationale
The central nervous system (CNS), memory, and cognition are not typically impacted by myasthenia gravis. This disorder primarily involves peripheral nervous system issues that affect voluntary muscle control rather than cognitive functions. Myasthenia gravis does not cause alterations in memory or cognition as seen with central nervous system disorders like Alzheimer's disease.
Choice C rationale
Myasthenia gravis notably affects respiratory and facial muscles. The autoimmune attack on acetylcholine receptors leads to muscle weakness, particularly in muscles controlling eye movements, facial expressions, and breathing. Patients may experience difficulty breathing, swallowing, and maintaining an open airway due to this muscle weakness.
Choice D rationale
The cardiovascular system and postural muscles are not commonly affected by myasthenia gravis. This condition involves the neuromuscular junction and leads to fatigue in voluntary muscles, primarily those involved in eye movement, facial expressions, and respiration. Cardiovascular symptoms are not a direct consequence of myasthenia gravis.
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