When involved in phase III drug evaluation studies, what responsibilities would the nurse have?
Working with animals who are given experimental drugs.
Conducting research to determine the effectiveness of the drug.
Monitoring and observing patients closely for adverse effects.
Choosing appropriate patients to be involved in the study.
The Correct Answer is C
Choice A rationale
Working with animals is typically done in preclinical trials before phase I studies in humans and is not part of phase III drug evaluation studies.
Choice B rationale
Conducting research to determine the effectiveness of the drug is part of phase II studies. Phase III studies focus more on confirming effectiveness, monitoring side effects, and comparing it to commonly used treatments.
Choice C rationale
Monitoring and observing patients closely for adverse effects is a key responsibility in phase III drug evaluation studies. These studies involve a larger patient population to gather comprehensive safety and efficacy data.
Choice D rationale
Choosing appropriate patients to be involved in the study is primarily the responsibility of researchers and clinicians during the earlier phases of drug development, such as phase I and phase II studies.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A rationale
The rebound effect is typically associated with decongestants rather than topical nasal steroids. It occurs when nasal congestion worsens after stopping decongestant use.
Choice B rationale
Local ulceration is a potential adverse reaction to topical nasal steroids due to the localized irritation and thinning of the nasal mucosa with prolonged use.
Choice C rationale
Increased nasal drainage is not a common adverse reaction to topical nasal steroids. These medications typically reduce inflammation and decrease nasal drainage.
Choice D rationale
Suppression of healing is not an adverse reaction associated with topical nasal steroids. These drugs are more likely to reduce inflammation and promote healing of the nasal mucosa.
Correct Answer is D
Explanation
Choice A rationale
Increased jugular venous pressure is more commonly associated with right-sided heart failure, where blood backs up into the venous system.
Choice B rationale
Liver enlargement is also indicative of right-sided heart failure due to congestion of the liver blood vessels.
Choice C rationale
Increased pulse rate can occur in both left and right-sided heart failure but is not a specific indicator of worsening left-sided failure.
Choice D rationale
Increased crackles in lung fields indicate fluid accumulation in the lungs, a sign of worsening left-sided heart failure. Left-sided heart failure leads to pulmonary congestion due to inadequate pumping of blood from the left ventricle.
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