The nurse gives 800 mg of a drug that has a half-life of 8 hours. How much drug will be left in the body in 24 hours if no additional drug is given?

None

50 mg

100 mg

200 mg

Answer and Explanation

The Correct Answer is C

A. The statement that no drug remains is incorrect. A drug with a half-life of 8 hours will not be completely eliminated in 24 hours, as it follows a predictable pattern of reduction.

B. A reduction to 50 mg would require additional half-life intervals beyond 24 hours. The drug concentration decreases by half every 8 hours, meaning it would take more than 24 hours to reach this level.

C. The correct calculation follows the half-life principle:

- At 8 hours: 800 mg → 400 mg

- At 16 hours: 400 mg → 200 mg

- At 24 hours: 200 mg → 100 mg

Therefore, 100 mg of the drug remains after 24 hours.

D. While 200 mg is a step in the process, it represents the amount remaining after only 16 hours, not the full 24-hour period.

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Correct Answer is A

Explanation

A. Bioavailability refers to the proportion of a drug that enters systemic circulation and is available for therapeutic effect. Generic drugs must demonstrate bioequivalence to brand-name drugs, meaning their bioavailability must be within an acceptable range to ensure similar efficacy.

B. Critical concentration is the minimum drug level required to produce a therapeutic effect, but it is not the primary factor in generic drug substitution.

C. Distribution refers to how a drug is transported in the body after absorption, but it is not the main concern when substituting generic drugs.

D. Half-life is the time required for the drug concentration to decrease by half in the body, but it does not determine whether a generic drug can replace a brand-name drug. Bioavailability is the key factor in ensuring therapeutic equivalence.

A. Clarify the order with the charge nurse B. Dilute the medication and administer by GT C. Clarify the order with the health provider who wrote the order D. Administer p.o as ordered

Correct Answer is C

Explanation

a) Clarifying the order with the charge nurse is not the correct action. The charge nurse may not be able to clarify medication orders and is not the primary contact for this issue.

b) Diluting and administering the medication by gastrostomy tube (GT) is inappropriate because the medication is ordered to be taken p.o. (by mouth), not via the tube.

c) Clarifying the order with the healthcare provider is the most appropriate step. A p.o. order is typically for oral administration, but the client has a gastrotomy tube. The nurse should clarify with the provider whether the medication can be crushed and administered via the tube or if a different route or medication form is necessary.

d) Administering the medication p.o. as ordered would not be appropriate if the client is unable to take oral medications. The nurse should verify the appropriate route of administration based on the patient's condition.

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The nurse gives 800 mg of a drug that has a half-life of 8 hours. How much drug will be left in the body in 24 hours if no additional drug is given?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

What concept is considered when generic drugs are substituted for brand-name drugs?

Correct Answer is A

Explanation

A client has a gastrotomy tube in place. The health care provider ordered the medication p.o. Which action would be appropriate for the nurse to take?

Correct Answer is C

Explanation

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