What factors can influence drug absorption? (Select all that apply)

Lung function

Kidney function

Liver function

Route of administration

Answer and Explanation

The Correct Answer is C

a) Lung function primarily affects gas exchange and respiratory function but does not significantly influence drug absorption.

b) Kidney function is important for drug excretion rather than absorption. It impacts drug elimination and toxicity risk rather than how well a drug is absorbed.

c) Liver function plays a key role in drug metabolism. Poor liver function can alter drug absorption and metabolism, particularly for orally administered drugs that undergo the first-pass effect.

d) The route of administration directly impacts drug absorption. For example, intravenous (IV) drugs bypass absorption entirely, while oral medications must go through the digestive system before entering circulation.

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Correct Answer is C

Explanation

A. The statement that no drug remains is incorrect. A drug with a half-life of 8 hours will not be completely eliminated in 24 hours, as it follows a predictable pattern of reduction.

B. A reduction to 50 mg would require additional half-life intervals beyond 24 hours. The drug concentration decreases by half every 8 hours, meaning it would take more than 24 hours to reach this level.

C. The correct calculation follows the half-life principle:

- At 8 hours: 800 mg → 400 mg

- At 16 hours: 400 mg → 200 mg

- At 24 hours: 200 mg → 100 mg

Therefore, 100 mg of the drug remains after 24 hours.

D. While 200 mg is a step in the process, it represents the amount remaining after only 16 hours, not the full 24-hour period.

A. To ensure a drug is tested for harmful effects. B. To ensure a drug has accurate labeling. C. To ensure a drug is free from adverse reactions. D. To ensure a drug is affordable. E. To ensure a drug is effective.

Correct Answer is ["A","B","E"]

Explanation

a) The FDA is responsible for overseeing the testing of drugs for harmful effects, including preclinical trials and clinical trials, to ensure that drugs do not cause unsafe side effects.

b) The FDA ensures that drugs have accurate labeling, including correct dosage, potential side effects, contraindications, and proper use.

c) The FDA does not guarantee that a drug will be free from adverse reactions. While they regulate and monitor drugs, adverse reactions can still occur after approval, and it is the responsibility of healthcare professionals and the manufacturer to monitor for these post-marketing.

d) The FDA does not ensure drug affordability; the pricing of drugs is influenced by many factors, including market forces, healthcare policies, and manufacturer decisions.

e) The FDA ensures that drugs are effective by overseeing clinical trials to demonstrate that the drug has the intended therapeutic effects for its indicated use.

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What factors can influence drug absorption? (Select all that apply)

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

The nurse gives 800 mg of a drug that has a half-life of 8 hours. How much drug will be left in the body in 24 hours if no additional drug is given?

Correct Answer is C

Explanation

Which are responsibilities of the FDA? (Select all that apply.)

Correct Answer is ["A","B","E"]

Explanation

When involved in phase III drug evaluation studies, which responsibilities would the nurse have?

When taking a medication history on a patient, why should the nurse ask about the use of complementary or alternative therapies?

In response to the patient's question about how to know whether drugs are safe, the nurse explains that all medications undergo rigorous scientific testing controlled by what organization?

What factors can influence drug absorption? (Select all that apply)

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Which statement about the safety and efficacy of medications in children is accurate?

The nurse, assisting with Phase I drug studies, is talking with a woman who asks, “Why can't I participate in this study”? What would be the nurse's best response?