The nurse is teaching a class about Irritable Bowel Syndrome. Which statement should not be included?

Choice A reason: In fever, pyrogens reset the hypothalamic thermoregulatory set point, causing the body to raise core temperature via shivering and vasoconstriction. Once reached, diaphoresis and flushing occur to dissipate heat, preventing overheating. This statement accurately describes the body’s response to achieving the fever’s set point in pneumonia.

Choice B reason: Exogenous pyrogens (e.g., bacterial toxins) act via endogenous pyrogens (cytokines) to reset the hypothalamic, not anterior pituitary, set point. The pituitary regulates hormones, not thermoregulation. This statement is inaccurate, as it misidentifies the anatomical site and mechanism of fever induction.

Choice C reason: Hyperthermia involves uncontrolled heat gain (e.g., heat stroke), not a regulated fever like in pneumonia. The client’s diaphoresis and flushing indicate intact heat loss mechanisms, not failure. This statement is inaccurate, as fever, not hyperthermia, drives the observed symptoms in this scenario.

Choice D reason: Endogenous pyrogens (e.g., IL-1, IL-6) stimulate prostaglandins, not leukotrienes, to reset the hypothalamic set point in fever. Leukotrienes are involved in allergic responses, not thermoregulation. This statement is inaccurate, as it misattributes the biochemical mediator of fever in pneumonia.

Choice A reason: Redirecting the client to the provider avoids addressing the question and misses an educational opportunity. Liver disease affects drug metabolism, and the nurse can explain this. This response is inappropriate, as it fails to provide the client with accurate information about their medication adjustments.

Choice B reason: Medication dose changes in liver disease are due to impaired metabolism, not dependency concerns. Dependency is unrelated to hepatic function or pharmacokinetics. This statement is inaccurate, as it misrepresents the reason for dose adjustments in the context of liver disease.

Choice C reason: Liver disease impairs drug metabolism via cytochrome P450 enzymes, reducing clearance and increasing drug levels, risking toxicity. Dose adjustments prevent adverse effects. This statement is accurate, as it directly addresses how liver dysfunction necessitates lower doses for safe and effective medication use.

Choice D reason: Medication affinity (binding to receptors) is not significantly altered by liver disease. Instead, impaired hepatic metabolism affects drug clearance, not receptor interactions. This statement is inaccurate, as it misattributes dose changes to a pharmacological property unrelated to liver function.