Prednisone is an oral corticosteroid that has less mineralocorticoid activity than other oral steroids. What does the nurse expect when giving this medication?

Choice A reason: Antidepressants, like SSRIs or tricyclics, require 3-6 weeks to achieve full therapeutic effect due to gradual neuroplastic changes, including upregulation of serotonin or norepinephrine receptors. Initial synaptic monoamine increases take time to translate into mood improvement, making this statement accurate and reassuring for the patient.

Choice B reason: Expecting symptom improvement within 7 days is unrealistic, as antidepressants require weeks to alter brain chemistry effectively. Suggesting immediate follow-up implies treatment failure prematurely, which is inaccurate. Monitoring is needed, but this statement misrepresents the typical timeline for antidepressant efficacy.

Choice C reason: Lack of symptom relief in 5-7 days does not necessitate switching medications, as antidepressants typically take 3-6 weeks for effect. Early non-response does not indicate failure, as synaptic and receptor adaptations are gradual. This statement is inaccurate and may lead to unnecessary medication changes.

Choice D reason: Incomplete symptom relief at 7 days is normal, but stating remaining symptoms are permanent is inaccurate. Antidepressants often achieve partial or full response by 6-8 weeks, and adjustments can optimize outcomes. This statement is misleading, as it falsely suggests persistent symptoms are unchangeable.

Choice A reason: Avoiding pain medication may increase discomfort, reducing mobility and increasing complications like atelectasis. Opioids can cause constipation, but this is managed with stool softeners, not avoidance. This statement is inaccurate, as pain control is essential for recovery and does not directly support wound healing.

Choice B reason: Excessive rest increases risks like venous thromboembolism or pneumonia, especially in obese patients. Early ambulation promotes circulation and wound healing without straining incisions if done cautiously. This statement is inaccurate, as limiting movement excessively hinders recovery and increases postoperative complications.

Choice C reason: Returning to normal activity too soon risks incision dehiscence or infection, particularly in obese patients with higher wound complication rates. Gradual activity increase under medical guidance is needed. This statement is inaccurate, as premature activity resumption can compromise healing and safety post-surgery.

Choice D reason: Adequate nutrition, especially high-protein intake, supports collagen synthesis and tissue repair, critical for wound healing. Obesity increases metabolic demand, and protein prevents malnutrition, enhancing immune response and incision strength. This statement is accurate, as nutrition is a priority to optimize postoperative recovery and prevent complications.