The patient is instructed when taking calcium channel blockers to use extreme caution when taking which of the following medications?

A. Nitroglycerin typically causes vasodilation and can lower blood pressure, rather than causing hypertension.

B. Diuresis, or increased urine production, is not a common adverse effect of nitroglycerin.

C. Nitroglycerin may cause a slight decrease in heart rate (bradycardia), but headache is a more common adverse effect.

D. Headache is the most common adverse effect of nitroglycerin, especially when first starting the medication or with dosage adjustments, due to vasodilation of blood vessels, including those in the head.

A. Orange juice does not interact with simvastatin and does not need to be avoided.

B. Coenzyme Q10 (CoQ10) supplements are sometimes taken by patients on statins to help alleviate the side effects like muscle pain, but they do not need to be avoided.

C. Grapefruit juice should be avoided while taking simvastatin because it contains compounds that interfere with the enzymes that metabolize statins, potentially leading to increased drug levels and greater risk of side effects such as muscle damage.

D. Not all fruit juices interact with simvastatin; the specific concern is with grapefruit juice.