What is the formulation on the drug label below?
Tablets
Lozenge
Elixir
Capsules
The Correct Answer is A
A. Tablets: The drug label clearly states "Zoloft (sertraline hydrochloride) tablets," indicating that this formulation is in tablet form. It also mentions "30 Tablets" directly below the dosage strength, confirming the correct formulation.
B. Lozenge: Lozenges are designed to dissolve slowly in the mouth for local effect and are not typically used for systemic antidepressants like sertraline. This formulation is not indicated on the label.
C. Elixir: An elixir is a liquid form of medication containing alcohol, and although sertraline can be made in liquid form, this label specifically refers to tablets, not a liquid preparation.
D. Capsules: Capsules contain medication enclosed in a gelatin shell, often used for extended-release purposes. The label does not mention capsules and explicitly says "tablets," making this option incorrect.
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Related Questions
Correct Answer is D
Explanation
A. The Cytochrome P-450 Enzyme System: This system plays a major role in drug metabolism, particularly in the liver, but it does not significantly affect drug distribution. Its primary influence is on the biotransformation of drugs into active or inactive metabolites.
B. Renal function: Renal function primarily affects drug excretion. Impaired kidney function can lead to drug accumulation and toxicity but has a minimal direct effect on the distribution of drugs throughout tissues and organs.
C. Gastric pH: Gastric pH influences drug absorption in the gastrointestinal tract, especially for pH-sensitive drugs. However, it plays little to no role in the actual distribution of the drug once it enters systemic circulation.
D. Blood flow: Blood flow is the most significant factor affecting drug distribution. Highly perfused organs like the brain, liver, and kidneys receive drugs more quickly and in higher concentrations than poorly perfused tissues, influencing the onset and intensity of drug action.
Correct Answer is B
Explanation
A. Apply the drops directly onto the patient's cornea: Eye drops should be instilled into the conjunctival sac, not directly onto the cornea. The cornea is highly sensitive, and direct application can cause discomfort, injury, and decreased patient adherence.
B. Perform punctal occlusion after instilling the drops: Punctal occlusion (gentle pressure on the inner corner of the eye) for 1–2 minutes reduces systemic absorption of the drug via the nasolacrimal duct. This is especially important with beta-blockers like Timolol, which can cause systemic effects such as bradycardia and hypotension.
C. Administer the medication immediately after meals: The timing of Timolol eye drops is not dependent on meals. Food intake has no impact on the efficacy or absorption of ophthalmic medications.
D. Instruct the patient to blink rapidly after instillation: Blinking rapidly can cause the medication to be expelled from the eye, reducing its effectiveness. Patients should be instructed to gently close the eye for a minute or two to enhance absorption.
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