Which antitumor drug has a dual role of being an antibiotic?

Methotrexate

Antiestrogens

Corticosteroid

Doxorubicin (Doxil)

Answer and Explanation

The Correct Answer is D

Choice A rationale: Incorrect. Methotrexate is a chemotherapy drug and an immunosuppressant but not an antibiotic. It inhibits the metabolism of folic acid, which is necessary for cell replication, but it does not have antibiotic properties.

Choice B rationale: Incorrect. Antiestrogens are a class of drugs used to treat hormone-sensitive cancers like breast cancer by blocking the effects of estrogen. They are not antibiotics and do not have antimicrobial properties.

Choice C rationale: Incorrect. Corticosteroids are used in cancer treatment primarily to reduce inflammation and manage side effects of chemotherapy, such as nausea and allergic reactions. They have immunosuppressive properties but are not antibiotics.

Choice D rationale: Correct. Doxorubicin (Doxil) is an antitumor drug that also has antibiotic properties. It belongs to the anthracycline class of chemotherapy drugs and works by intercalating DNA, disrupting the replication and transcription processes, leading to cell death. Doxorubicin was originally derived from the bacterium Streptomyces peucetius, which imparts its antibiotic properties.

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Correct Answer is C

Explanation

A. Hypotension

While diphenhydramine can cause drowsiness and may contribute to orthostatic hypotension, it is not a strict contraindication. However, caution should be exercised in patients with hypotension.

B. Allergy to penicillin

An allergy to penicillin is not directly related to the use of diphenhydramine. Allergies to specific medications, including penicillin, are important to assess but are not a primary concern when administering diphenhydramine.

C. Narrow-angle glaucoma

Diphenhydramine can cause pupil dilation and may worsen narrow-angle glaucoma, leading to increased intraocular pressure. Therefore, it is crucial to assess for a history of narrow-angle glaucoma before administering diphenhydramine. If a patient has a history of this condition, alternative medications or careful monitoring may be necessary.

D. Diabetes insipidus

Diabetes insipidus is not typically a contraindication for diphenhydramine. However, it is essential to consider the overall health status and specific needs of the patient. Diphenhydramine may have anticholinergic effects, and caution is advised in patients with certain medical conditions.

A. Avoid elevated altitudes of greater than 2,000 feet (if possible) and air travel for 2-4 weeks (depending on the oncologist’s advice). B. Avoid foods high in purine for 30-90 days (depending on the oncologist’s advice). C. Avoid sun exposure for 60-90 days following chemotherapy (depending on oncologist’s advice). D. Have a solid plan for contraception for 3 months to 2 years (depending on the oncologist’s advice).

Correct Answer is C

Explanation

A. Avoid elevated altitudes of greater than 2,000 feet (if possible) and air travel for 2-4 weeks (depending on the oncologist’s advice):

Altitude and air travel restrictions are not common recommendations after completing chemotherapy.

B. Avoid foods high in purine for 30-90 days (depending on the oncologist’s advice):

Restrictions on foods high in purine are not typically associated with post-chemotherapy care.

C. Avoid sun exposure for 60-90 days following chemotherapy (depending on oncologist’s advice):

Chemotherapy can make the skin more sensitive to sunlight. Advising the patient to avoid sun exposure or take precautions such as using sunscreen can help prevent skin damage during this period.

D. Have a solid plan for contraception for 3 months to 2 years (depending on the oncologist’s advice):

Contraception considerations may be important, but the timeframe mentioned is not a standard recommendation following chemotherapy completion. The need for contraception may vary depending on the patient's overall health, reproductive goals, and specific chemotherapy drugs received. This decision is usually discussed with the healthcare provider on an individual basis.

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Which antitumor drug has a dual role of being an antibiotic?

Nursing Test Bank

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Correct Answer is C

Explanation

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Correct Answer is C

Explanation

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