Which arterial blood gas (ABG) data corresponds with a patient's clinical manifestations of respiratory alkalosis?

pH = 7.46, PaCO2 = 44 mm Hg, PaO2 = 95 mm Hg, and HCO3 = 36 mEq/L.

pH = 7.27, PaCO2 = 70 mm Hg, PaO2 = 80 mm Hg, and HCO3 = 26 mEq/L.

pH = 7.30, PaCO2 = 35 mm Hg, PaO2 = 70 mm Hg, and HCO3 = 20 mEq/L.

pH = 7.52, PaCO2 = 24 mm Hg, PaO2 = 85 mm Hg, and HCO3 = 24 mEq/L.

Answer and Explanation

The Correct Answer is D

The correct answer is Choice D. Then start with Choice A rationale:

Choice A is incorrect because it represents metabolic alkalosis, not respiratory alkalosis. Metabolic alkalosis occurs when there is a primary increase in the bicarbonate (HCO3) level, which causes the pH to rise above the normal range (7.35-7.45). The PaCO2 is normal in this case, indicating that the respiratory system is not involved in the acid-base imbalance. Some causes of metabolic alkalosis include vomiting, diuretic use, excessive antacid intake, and mineralocorticoid excess 1.

Choice B is incorrect because it represents respiratory acidosis, not respiratory alkalosis. Respiratory acidosis occurs when there is a primary decrease in the PaCO2 level, which causes the pH to fall below the normal range. The HCO3 is normal in this case, indicating that the metabolic system is not involved in the acid-base imbalance. Some causes of respiratory acidosis include hypoventilation, airway obstruction, chest trauma, neuromuscular disorders, and chronic lung diseases 2.

Choice C is incorrect because it represents metabolic acidosis, not respiratory alkalosis. Metabolic acidosis occurs when there is a primary decrease in the HCO3 level, which causes the pH to fall below the normal range. The PaCO2 is normal in this case, indicating that the respiratory system is not involved in the acid-base imbalance. Some causes of metabolic acidosis include diabetic ketoacidosis, lactic acidosis, renal failure, diarrhea, and poisoning 3.

Choice D is correct because it represents respiratory alkalosis. Respiratory alkalosis occurs when there is a primary decrease in the PaCO2 level, which causes the pH to rise above the normal range. The HCO3 is normal in this case, indicating that the metabolic system is not involved in the acid-base imbalance. Some causes of respiratory alkalosis include hyperventilation, anxiety, panic, fever, pain, tumor, trauma, severe anemia, liver disease, overdose of certain medicines, pulmonary embolism, pregnancy, and any lung disease that leads to shortness of breath . Respiratory alkalosis is characterized by symptoms such as breathlessness, dizziness, numbness, tingling, muscle spasms, chest discomfort, confusion, and fainting.

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Correct Answer is C

Explanation

Choice A rationale:

Serotonin is a neurotransmitter that plays a role in mood regulation, sleep, and other functions in the body. It is not a component that forms an adhesive bridge between platelets and vascular subendothelial structures in the clotting process.

Choice B rationale:

Platelet factor III is not a component that forms an adhesive bridge between platelets and vascular subendothelial structures in the clotting process. Platelet factor III is not widely recognized in the context of clotting; it is more commonly referred to as tissue factor and is involved in the extrinsic pathway of coagulation.

Choice C rationale:

Von Willebrand factor (VWF) is a protein that plays a crucial role in hemostasis. It forms an adhesive bridge between platelets and vascular subendothelial structures, particularly at sites of vascular injury. VWF helps platelets adhere to the injured vessel wall, leading to the formation of a stable blood clot. This process is essential for preventing excessive bleeding. A deficiency or dysfunction in VWF can lead to von Willebrand disease, a bleeding disorder characterized by prolonged bleeding times.

Choice D rationale:

Adenosine diphosphate (ADP) is a molecule released by platelets when they are activated. ADP helps in the aggregation of platelets, but it does not directly form an adhesive bridge between platelets and vascular subendothelial structures.

A. Hemophilia is not hereditary in nature. B. Hemophilia can be treated by replacement therapy. C. Hemophilia is an X-linked dominant genetic disorder. D. Hemophilia B is the most common form of hemophilia.

Correct Answer is B

Explanation

Choice A rationale:

Hemophilia is a hereditary disorder caused by a deficiency of specific clotting factors, and it is indeed hereditary in nature. This statement is incorrect.

Choice B rationale:

Hemophilia is a bleeding disorder where the blood does not clot properly. Replacement therapy, which involves infusing clotting factor concentrates, is a standard treatment for hemophilia. This statement is correct.

Choice C rationale:

Hemophilia is an X-linked recessive genetic disorder, not dominant. Males are more commonly affected because they have only one X chromosome, and if it carries the defective gene, they will have hemophilia. Females have two X chromosomes, and if one X chromosome carries the defective gene, the other X chromosome can compensate, making them carriers but not typically affected.

Choice D rationale:

Hemophilia A is the most common form of hemophilia, not hemophilia B.

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Which arterial blood gas (ABG) data corresponds with a patient's clinical manifestations of respiratory alkalosis?

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Naxlex Comprehensive Predictor Exams

Which component forms an adhesive bridge between platelets and vascular subendothelial structures in the clotting process?

Correct Answer is C

Explanation

Which statement is true regarding hemophilia?

Correct Answer is B

Explanation

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