Which inflammatory mediators cause the clinical manifestations of asthma?

Macrophages, monocytes, bradykinin.

B lymphocytes, serotonin, immunoglobulin D.

Histamine, leukotrienes, prostaglandins.

Helper T lymphocytes, natural killer cells, interleukin-1.

Answer and Explanation

The Correct Answer is C

Choice A reason: Macrophages, monocytes, and bradykinin are involved in the inflammatory response, but they do not directly cause the symptoms of asthma. They may activate other cells and mediators that contribute to bronchoconstriction and mucus production.

Choice B reason: B lymphocytes, serotonin, and immunoglobulin D are not major players in the pathophysiology of asthma. B lymphocytes produce immunoglobulins, but immunoglobulin E (IgE) is the main antibody involved in allergic asthma. Serotonin is a neurotransmitter that may affect mood and sleep, but it does not cause bronchospasm. Immunoglobulin D is a rare antibody that has no known role in asthma.

Choice C reason: Histamine, leukotrienes, and prostaglandins are the main inflammatory mediators that cause the clinical manifestations of asthma. They are released by mast cells and other cells in response to allergens or irritants. They cause bronchial smooth muscle contraction, increased vascular permeability, edema, mucus secretion, and airway inflammation.

Choice D reason: Helper T lymphocytes, natural killer cells, and interleukin-1 are involved in the immune response, but they do not directly cause the symptoms of asthma. They may modulate the activation and differentiation of other cells and mediators that contribute to airway hyperresponsiveness and inflammation.

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Correct Answer is B

Explanation

Choice A reason: Numbness and tingling of the fingers and toes is not the expected finding because it is a sign of alkalosis, not acidosis. Alkalosis is a condition where the blood has a high pH, which means that it is too basic or alkaline. Alkalosis can cause numbness and tingling of the fingers and toes due to hypocalcemia, which is a low level of calcium in the blood, or hypokalemia, which is a low level of potassium in the blood. Both conditions can affect the nerve and muscle function, causing paresthesia, which is an abnormal sensation of the skin.

Choice B reason: A diffuse headache described as "throbbing" is the expected finding because it is a sign of acidosis, which is a condition where the blood has a low pH, which means that it is too acidic. Acidosis can cause a diffuse headache described as "throbbing" due to vasodilation, which is the widening of the blood vessels, especially in the brain. Vasodilation can increase the blood flow and the pressure in the head, causing pain and discomfort.

Choice C reason: Flushed skin that is warm to the touch is not the expected finding because it is a sign of fever, not salicylate toxicity. Fever is a condition where the body temperature is higher than normal, usually due to an infection or inflammation. Fever can cause flushed skin that is warm to the touch due to increased blood flow to the skin, which helps to dissipate the excess heat.

Choice D reason: Decreased muscle strength and deep tendon reflexes is not the expected finding because it is a sign of neuromuscular blockade, not salicylate toxicity. Neuromuscular blockade is a condition where the communication between the nerves and the muscles is impaired, causing paralysis or weakness. Neuromuscular blockade can be caused by various factors, such as medications, toxins, or diseases, that interfere with the transmission of acetylcholine, which is a neurotransmitter that stimulates the muscle contraction.

A. Serum osmolality 380 mOsm/kg B. Urine output of 500 mL in 24 hours C. Weight gain of 5 pounds in 48 hours D. Decreased serum hematocrit levels

Correct Answer is A

Explanation

Choice A reason: Serum osmolality 380 mOsm/kg is the expected finding because it is a sign of dehydration, which is a common complication of diabetes insipidus. Diabetes insipidus is a condition where the body does not produce enough antidiuretic hormone (ADH), which is a hormone that helps the kidneys retain water and regulate the fluid balance in the body. A severe traumatic brain injury can damage the pituitary gland or the hypothalamus, which are parts of the brain that produce and secrete ADH. Without enough ADH, the kidneys produce large amounts of diluted urine, which causes the loss of water and electrolytes from the body. This increases the concentration of solutes in the blood, which is measured by the serum osmolality. A normal serum osmolality is between 275 and 295 mOsm/kg, while a high serum osmolality is above 300 mOsm/kg.

Choice B reason: Urine output of 500 mL in 24 hours is not the expected finding because it is a sign of oliguria, which is a low urine output. Oliguria can be caused by various factors, such as dehydration, kidney failure, or urinary obstruction, and can result in symptoms such as fluid retention, swelling, or electrolyte imbalance. Oliguria is not a common finding in diabetes insipidus, because the condition causes polyuria, which is a high urine output. Polyuria can be defined as urine output of more than 3 liters in 24 hours, or more than 200 mL per hour.

Choice C reason: Weight gain of 5 pounds in 48 hours is not the expected finding because it is a sign of fluid overload, which is a condition where the body retains too much fluid, which can cause edema, hypertension, and heart failure. Fluid overload can be caused by various factors, such as heart failure, kidney failure, or liver failure, and can result in symptoms such as shortness of breath, chest pain, or fatigue. Fluid overload is not a common finding in diabetes insipidus, because the condition causes dehydration, which is a loss of fluid from the body. Dehydration can cause weight loss, not weight gain.

Choice D reason: Decreased serum hematocrit levels is not the expected finding because it is a sign of anemia, which is a condition where the blood has a low level of hemoglobin, which is the protein that carries oxygen in the red blood cells. Anemia can be caused by various factors, such as blood loss, iron deficiency, or bone marrow failure, and can result in symptoms such as fatigue, weakness, or pallor. Anemia is not a common finding in diabetes insipidus, because the condition does not affect the production or function of the red blood cells. Diabetes insipidus can cause increased serum hematocrit levels, not decreased, because the loss of water from the body can increase the proportion of red blood cells in the blood.

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Which inflammatory mediators cause the clinical manifestations of asthma?

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Naxlex Comprehensive Predictor Exams

The nurse provides care for a client admitted one hour ago with the diagnosis of salicylate toxicity. The client has an arterial pH of 7.32. Which finding does the nurse expect to observe?

Correct Answer is B

Explanation

A client developed diabetes insipidus as a result of a severe traumatic brain injury. Which finding does the nurse expect to observe?

Correct Answer is A

Explanation

Which inflammatory mediators cause the clinical manifestations of asthma?

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