Which medication is most likely to increase urine flow?
Furosemide
Spironolactone
Hydrochlorothiazide
Mannitol
The Correct Answer is A
Choice A reason: Furosemide, a loop diuretic, inhibits the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle, preventing sodium and water reabsorption. This increases urine output significantly, often within minutes, making it highly effective for conditions like edema or heart failure, producing a rapid diuresis of up to 20% of filtered sodium.
Choice B reason: Spironolactone, a potassium-sparing diuretic, inhibits aldosterone in the distal tubule, reducing sodium reabsorption and increasing urine output. However, its diuretic effect is weaker than furosemide, as it affects only 2-3% of filtered sodium. It is primarily used for managing hyperaldosteronism or potassium retention, not rapid urine flow increase.
Choice C reason: Hydrochlorothiazide, a thiazide diuretic, inhibits sodium-chloride reabsorption in the distal convoluted tubule, increasing urine output. Its effect is milder than furosemide, impacting about 5-10% of filtered sodium. It is commonly used for hypertension but is less potent for rapid diuresis in conditions requiring significant urine flow.
Choice D reason: Mannitol, an osmotic diuretic, increases urine flow by preventing water reabsorption in the proximal tubule and loop of Henle. It is effective in acute settings like cerebral edema but less commonly used for routine diuresis compared to furosemide, which has a broader and more rapid effect on urine output.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Choice A reason: Negative glucose in urine is normal, as the kidneys reabsorb glucose unless blood levels exceed 180 mg/dL (e.g., in diabetes). In hypertension, this finding does not indicate renal damage or require further assessment, as it aligns with normal renal function and glucose handling.
Choice B reason: Negative white blood cells in urine suggest no urinary tract infection or inflammation, a normal finding. In hypertensive patients, this does not signal kidney damage or other complications, so no additional assessment is needed, as it indicates an absence of acute inflammatory processes.
Choice C reason: Proteinuria (positive protein) indicates potential renal damage, common in hypertension due to glomerular injury from elevated pressure. It suggests impaired filtration, allowing proteins like albumin to leak into urine. This finding warrants further assessment, such as quantifying protein levels or evaluating kidney function, making it the correct choice.
Choice D reason: Creatinine in urine is normal, as it is a waste product excreted by the kidneys. While serum creatinine assesses renal function, urinary creatinine presence is expected and does not indicate pathology in hypertension, so it does not require additional assessment in this context.
Correct Answer is A
Explanation
Choice A reason: Osteoporosis causes bone density loss, leading to fractures, not primary joint pain. Pain occurs secondary to fractures, not joint inflammation or degeneration. This condition is the least likely to cause joint pain directly, as its pathology focuses on bone fragility rather than synovial or cartilage issues.
Choice B reason: Systemic lupus erythematosus (SLE) causes joint pain due to autoimmune-mediated synovitis, affecting multiple joints symmetrically. Inflammatory cytokines drive pain and swelling, making SLE a common cause of joint pain, unlike osteoporosis, which primarily affects bone structure without direct joint involvement.
Choice C reason: Osteoarthritis causes joint pain due to cartilage degeneration and bone-on-bone friction, particularly in weight-bearing joints like knees. Mechanical stress and inflammation contribute to chronic pain, making osteoarthritis a frequent cause of joint pain, unlike osteoporosis, which lacks primary joint pathology.
Choice D reason: Rheumatoid arthritis causes significant joint pain through autoimmune synovial inflammation, leading to swelling, stiffness, and cartilage damage. This systemic condition affects multiple joints, making it a primary cause of joint pain, unlike osteoporosis, which is associated with bone loss, not joint inflammation.
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