Which statement about Crohn’s disease is accurate?

Choice A reason: Osteoporosis causes bone density loss, leading to fractures, not primary joint pain. Pain occurs secondary to fractures, not joint inflammation or degeneration. This condition is the least likely to cause joint pain directly, as its pathology focuses on bone fragility rather than synovial or cartilage issues.

Choice B reason: Systemic lupus erythematosus (SLE) causes joint pain due to autoimmune-mediated synovitis, affecting multiple joints symmetrically. Inflammatory cytokines drive pain and swelling, making SLE a common cause of joint pain, unlike osteoporosis, which primarily affects bone structure without direct joint involvement.

Choice C reason: Osteoarthritis causes joint pain due to cartilage degeneration and bone-on-bone friction, particularly in weight-bearing joints like knees. Mechanical stress and inflammation contribute to chronic pain, making osteoarthritis a frequent cause of joint pain, unlike osteoporosis, which lacks primary joint pathology.

Choice D reason: Rheumatoid arthritis causes significant joint pain through autoimmune synovial inflammation, leading to swelling, stiffness, and cartilage damage. This systemic condition affects multiple joints, making it a primary cause of joint pain, unlike osteoporosis, which is associated with bone loss, not joint inflammation.

Choice A reason: Achieving euthyroid state before hyperthyroidism procedures, like thyroidectomy, aims to normalize thyroid hormone levels, not prevent hypothyroidism. Post-procedure hypothyroidism is a separate concern managed with hormone replacement. This statement is inaccurate, as the primary goal is to stabilize metabolism, not prevent low thyroid function.

Choice B reason: Medications like methimazole or propylthiouracil are used pre-procedure to achieve euthyroid state, reducing thyroid hormone levels to prevent thyroid storm—a life-threatening hypermetabolic crisis triggered by surgery or stress. This statement is accurate, as stabilizing thyroid function minimizes perioperative complications like tachycardia or hyperthermia.

Choice C reason: Euthyroid state does not directly enhance the efficacy of anti-thyroid medications but rather prepares the patient for surgery by reducing hyperthyroid symptoms. Medications are effective independently, and this statement is inaccurate, as the rationale focuses on patient safety, not drug potentiation.

Choice D reason: While euthyroid state reduces metabolic stress, it does not primarily minimize bleeding risk. Bleeding is managed through surgical techniques and coagulation status, not thyroid hormone levels. This statement is inaccurate, as bleeding risk is not the primary concern addressed by achieving euthyroid state pre-procedure.