Which of the following are causes of intrarenal acute kidney injury? (Select all that apply.)
Hemoglobin from hemolyzed RBCs
Benign prostatic hyperplasia
Prostate cancer
Myoglobin release from necrotic muscle cells
Nephrotoxins
Correct Answer : A,D,E
Choice A rationale
Hemoglobin released from hemolyzed red blood cells (RBCs) can cause intrarenal acute kidney injury by obstructing the renal tubules and damaging the nephrons.
Choice B rationale
Benign prostatic hyperplasia is a cause of postrenal, not intrarenal, acute kidney injury as it can obstruct the flow of urine out of the bladder.
Choice C rationale
Prostate cancer, similar to benign prostatic hyperplasia, typically leads to postrenal acute kidney injury due to urinary obstruction.
Choice D rationale
Myoglobin released from necrotic muscle cells, as seen in conditions like rhabdomyolysis, can cause intrarenal acute kidney injury by precipitating in the renal tubules.
Choice E rationale
Nephrotoxins, such as certain medications, chemicals, or toxins, can directly damage the kidney tissue, leading to intrarenal acute kidney injury.
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Related Questions
Correct Answer is A
Explanation
Choice A rationale
In prerenal AKI, the kidneys are not receiving enough blood flow. As a result, they cannot filter potassium out of the blood efficiently, leading to hyperkalemia, which is an elevated level of potassium in the blood. This condition is dangerous because it can cause cardiac dysrhythmias and muscle weakness.
Choice B rationale
Hypernatremia, an elevated sodium level, is not typically associated with prerenal AKI. It is more commonly related to dehydration or an excessive intake of sodium, which are not direct consequences of prerenal AKI.
Choice C rationale
Hypercalcemia, an elevated calcium level, is also not a common finding in prerenal AKI. It is usually associated with other conditions such as hyperparathyroidism or malignancy.
Choice D rationale
Hypophosphatemia, a low level of phosphate in the blood, is not a typical result of prerenal AKI. It can occur due to malnutrition or malabsorption, but it is not directly caused by prerenal AKI.
Correct Answer is ["B","C"]
Explanation
Choice A rationale
While infections can occur in IBD, the primary goal is not to combat infection but to manage the underlying inflammation¹.
Choice B rationale
Controlling inflammation is a key treatment goal in IBD to alleviate symptoms and induce and maintain remission².
Choice C rationale
Correcting and preventing malnutrition is essential in IBD management due to potential nutrient absorption issues¹.
Choice D rationale
Increasing stress is not a treatment goal for IBD. In fact, reducing stress can help manage IBD symptoms².
Choice E rationale
While IBD currently has no cure, the goals are to manage symptoms, induce remission, and improve quality of life².
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