Choice A reason: Cushing's syndrome is caused by excess cortisol, a type of glucocorticoid hormone, in the body. This can result from overproduction of cortisol by the adrenal glands, or from prolonged use of corticosteroid medications. Elevated glucocorticoid level is the correct alteration in endocrine function for this condition.

Choice B reason: Decreased aldosterone level is not related to Cushing's syndrome. Aldosterone is another hormone produced by the adrenal glands, but it regulates the balance of sodium and potassium in the body. Decreased aldosterone level can cause low blood pressure, dehydration, and electrolyte imbalance.

Choice C reason: Elevated aldosterone secretion is also not related to Cushing's syndrome. Elevated aldosterone secretion can cause high blood pressure, fluid retention, and hypokalemia (low potassium level). This condition is known as hyperaldosteronism or Conn's syndrome.

Choice D reason: Diminished glucocorticoid level is the opposite of Cushing's syndrome. Diminished glucocorticoid level can cause low blood sugar, fatigue, weight loss, and poor stress response. This condition is known as Addison's disease or adrenal insufficiency.

Choice A reason: Purplish streaks on the abdomen are also known as striae. They are caused by the thinning and weakening of the skin due to excess cortisol, a hormone that is elevated in Cushing syndrome. Striae are a common sign of Cushing syndrome, along with weight gain, moon face, and buffalo hump.

Choice B reason: Chronically low blood pressure is not associated with Cushing syndrome. Cushing syndrome can cause high blood pressure, due to the effects of cortisol on the cardiovascular system. Low blood pressure can be a sign of adrenal insufficiency, which is the opposite of Cushing syndrome.

Choice C reason: Bronzed appearance of the skin is not related to Cushing syndrome. Bronzed skin can be a sign of Addison's disease, which is a condition of low cortisol and low aldosterone. Addison's disease can cause hyperpigmentation of the skin, especially in the areas exposed to sun, such as the face, neck, and hands.

Choice D reason: Decreased axillary and pubic hair is also not related to Cushing syndrome. Cushing syndrome can cause increased hair growth, especially on the face, chest, and back. This is due to the androgenic effects of cortisol. Decreased hair growth can be a sign of hypothyroidism, which is a condition of low thyroid hormone.

Choice A reason: I will always need to take hydrocortisone pills is a correct statement. Hydrocortisone is a synthetic form of cortisol, a hormone that is normally produced by the adrenal glands. After a bilateral adrenalectomy, the patient will have no adrenal glands and will need to take hydrocortisone pills for life to replace the missing hormone.

Choice B reason: I have a way to inject hydrocortisone in case of emergency is also a correct statement. Hydrocortisone injections are used to treat acute adrenal crisis, a life-threatening condition that can occur when the patient has low cortisol levels due to stress, illness, injury, or surgery. The patient should have an emergency kit with hydrocortisone injections and instructions on how to use them.

Choice C reason: I will stop taking hydrocortisone when I feel better is an incorrect statement. This indicates a need for further education regarding medications after a bilateral adrenalectomy. The patient should never stop taking hydrocortisone without consulting their doctor, as this can cause severe symptoms of adrenal insufficiency, such as low blood pressure, low blood sugar, weakness, fatigue, and confusion.

Choice D reason: I have nausea or vomiting often is a statement that requires further assessment by the nurse. Nausea or vomiting can be signs of inadequate or excessive hydrocortisone dosage, or other complications after a bilateral adrenalectomy. The nurse should monitor the patient's vital signs, blood glucose, electrolytes, and weight, and report any abnormal findings to the doctor. The patient may need to adjust their hydrocortisone dose or take other medications to manage their symptoms.

Choice A reason: Eating a piece of pizza is not a good option for the student. Pizza is a complex carbohydrate that contains fat and protein, which can delay the absorption of glucose and cause unpredictable blood sugar levels. The student needs a simple carbohydrate that can quickly raise her blood sugar level, such as glucose tablets, fruit juice, or candy.

Choice B reason: Taking an extra dose of rapid-acting insulin is a dangerous option for the student. Insulin lowers the blood sugar level, and the student already has symptoms of hypoglycemia (low blood sugar), such as headache, vision changes, and anxiety. Taking more insulin can worsen her condition and cause seizures, coma, or death.

Choice C reason: Eating 15 g of simple carbohydrates is the best option for the student. Simple carbohydrates are easily digested and absorbed into the bloodstream, and can raise the blood sugar level within 15 minutes. The student should eat 15 g of simple carbohydrates, such as four glucose tablets, half a cup of fruit juice, or three pieces of hard candy, and then check her blood sugar level if possible.

Choice D reason: Drinking some diet pop is not a helpful option for the student. Diet pop does not contain any sugar or calories, and will not affect the blood sugar level. The student needs a source of glucose to treat her hypoglycemia, and diet pop will not provide that.

Choice A reason: Weight loss is a common clinical manifestation of type 1 diabetes mellitus in children. Type 1 diabetes mellitus is a condition where the pancreas does not produce enough insulin, a hormone that helps the cells use glucose for energy. Without insulin, the glucose stays in the blood and causes high blood sugar levels. The body then breaks down fat and muscle for energy, resulting in weight loss.

Choice B reason: Low urine output is not a typical clinical manifestation of type 1 diabetes mellitus in children. In fact, the opposite is true: high urine output is a sign of type 1 diabetes mellitus. This is because the excess glucose in the blood draws water from the cells and tissues, causing dehydration and increased thirst. The kidneys then try to flush out the glucose and water through urine, leading to frequent urination.

Choice C reason: Weight gain is not a usual clinical manifestation of type 1 diabetes mellitus in children. As explained in choice A, type 1 diabetes mellitus causes weight loss due to the lack of insulin and the breakdown of fat and muscle. Weight gain can be a sign of type 2 diabetes mellitus, which is a condition where the cells become resistant to insulin and the pancreas cannot produce enough insulin to overcome the resistance. Weight gain can also be a side effect of insulin therapy, which is used to treat both types of diabetes mellitus.

Choice D reason: Hand tremors are not a specific clinical manifestation of type 1 diabetes mellitus in children. Hand tremors can be caused by many factors, such as anxiety, stress, caffeine, medication, or neurological disorders. Hand tremors can also be a symptom of hypoglycemia, which is a condition of low blood sugar that can occur in people with diabetes mellitus. However, hypoglycemia is not exclusive to diabetes mellitus, and can affect anyone who has a low intake of food, a high expenditure of energy, or a high dose of insulin or oral hypoglycemic agents.

Choice A reason: Urine dipstick for glucose is not a reliable test to evaluate the effectiveness of treatment for type 2 diabetes. Urine glucose testing can only detect glucose in the urine when the blood glucose level is very high, above the renal threshold of 180 mg/dL. Urine glucose testing does not reflect the average blood glucose level over time, and can be affected by factors such as hydration, medication, and urinary tract infections.

Choice B reason: Fasting blood glucose is a test that measures the blood glucose level after an overnight fast of at least 8 hours. Fasting blood glucose is a useful test to diagnose diabetes, but it is not the best test to evaluate the effectiveness of treatment for type 2 diabetes. Fasting blood glucose only reflects the blood glucose level at one point in time, and can vary depending on the time of day, the amount and type of food eaten, and the activity level.

Choice C reason: Oral glucose tolerance is a test that measures the blood glucose level before and after drinking a solution containing 75 g of glucose. Oral glucose tolerance is another test that can diagnose diabetes, but it is not the most convenient or accurate test to evaluate the effectiveness of treatment for type 2 diabetes. Oral glucose tolerance requires the patient to fast for at least 8 hours, drink the glucose solution, and have blood samples taken at 0, 30, 60, 90, and 120 minutes. Oral glucose tolerance can also be influenced by factors such as stress, illness, medication, and menstrual cycle.

Choice D reason: Glycosylated hemoglobin (Hemoglobin A1C) is a test that measures the percentage of hemoglobin that has glucose attached to it. Hemoglobin is a protein in the red blood cells that carries oxygen. Red blood cells have a lifespan of about 120 days, so the hemoglobin A1C test reflects the average blood glucose level over the past 2 to 3 months. Hemoglobin A1C is the best test to evaluate the effectiveness of treatment for type 2 diabetes, as it shows how well the blood glucose level has been controlled over time, and is not affected by factors such as fasting, food intake, or daily fluctuations.

Choice A reason: Patient stopped taking the medication 2 days ago is the most important information to report to the health care provider. Prednisone is a corticosteroid medication that suppresses the immune system and reduces inflammation. Prednisone also affects the production of cortisol, a hormone that regulates the stress response, blood pressure, blood sugar, and metabolism. Prednisone should not be stopped abruptly, as this can cause adrenal insufficiency, a condition where the adrenal glands cannot produce enough cortisol. Adrenal insufficiency can cause symptoms such as fatigue, weakness, nausea, vomiting, low blood pressure, and hypoglycemia. The patient should be instructed to resume taking the prednisone and taper the dose gradually under the supervision of the health care provider.

Choice B reason: Patient has not been taking the prescribed vitamin D is not as important as choice A, but still requires further education by the nurse. Vitamin D is a fat-soluble vitamin that helps the body absorb calcium and phosphorus, and maintain bone health. Prednisone can interfere with the metabolism of vitamin D and cause bone loss, osteoporosis, and fractures. The patient should be advised to take the prescribed vitamin D supplement and eat foods rich in vitamin D, such as fatty fish, egg yolks, cheese, and fortified milk.

Choice C reason: Patient has bilateral 2+ pitting ankle edema is not as critical as choice A, but still needs to be monitored by the nurse. Ankle edema is swelling of the ankles due to fluid accumulation in the tissues. Prednisone can cause ankle edema by increasing the sodium and water retention in the body, and reducing the potassium excretion by the kidneys. The patient should be assessed for signs of fluid overload, such as weight gain, shortness of breath, and crackles in the lungs. The patient should also be encouraged to limit the intake of salt and fluids, and elevate the legs when sitting or lying down.

Choice D reason: Patient's blood pressure is 148/94 mm Hg is not as urgent as choice A, but still needs to be addressed by the nurse. Blood pressure is the force of blood against the walls of the arteries. Prednisone can increase the blood pressure by stimulating the renin-angiotensin-aldosterone system, a hormonal system that regulates the blood volume and pressure. The patient should be advised to check the blood pressure regularly, and report any readings above 140/90 mm Hg to the health care provider. The patient should also be counseled to follow a healthy lifestyle, such as exercising, quitting smoking, reducing stress, and eating a balanced diet low in sodium, fat, and cholesterol.

Choice A reason: I will need to take medication by mouth until my blood sugar is within normal limits again is an incorrect statement that indicates the need for further teaching. Type 1 diabetes mellitus (DM) is a condition where the pancreas does not produce any insulin, a hormone that helps the cells use glucose for energy. Patients with type 1 DM need to take insulin injections or use an insulin pump for life to replace the missing hormone. Oral medications for diabetes are not effective for type 1 DM, as they work by stimulating the pancreas to produce more insulin or by increasing the sensitivity of the cells to insulin.

Choice B reason: If I get the flu, the dose of my insulin may need to be altered to control my blood glucose is a correct statement that shows understanding of the disease process. Illnesses such as the flu can increase the blood glucose level, as the body releases hormones that counteract the effects of insulin. Patients with type 1 DM may need to adjust their insulin dose, monitor their blood glucose more frequently, and check for ketones in their urine or blood when they are sick. Ketones are acidic substances that are produced when the body breaks down fat for energy, and can lead to a serious complication called diabetic ketoacidosis.

Choice C reason: I will monitor my blood glucose to help determine whether my medication is working as anticipated is another correct statement that demonstrates knowledge of the disease management. Blood glucose monitoring is an essential part of diabetes care, as it helps the patients and the health care providers to evaluate the effectiveness of the insulin therapy, the diet, and the exercise plan. Blood glucose monitoring also helps to prevent or detect hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar), and to adjust the insulin dose accordingly.

Choice D reason: The things that I eat may impact the dose of my medication used to control my blood glucose is also a correct statement that reflects awareness of the disease implications. The amount and type of carbohydrates that the patients eat can affect their blood glucose level, as carbohydrates are the main source of glucose in the diet. Patients with type 1 DM need to balance their insulin dose with their carbohydrate intake, and follow a consistent and healthy eating pattern. They may also use carbohydrate counting, a method of estimating the grams of carbohydrates in the foods they eat, to help them plan their meals and snacks.

Choice A reason: Metabolic acidosis is a condition where the blood pH is lower than normal, due to an excess of acids or a loss of bases in the body. Jo is most at risk of developing metabolic acidosis, because of the high blood glucose level. High blood glucose can cause diabetic ketoacidosis, a complication of Type 1 Diabetes, where the body breaks down fat for energy and produces ketones, which are acidic substances. Ketones can accumulate in the blood and lower the pH, causing symptoms such as nausea, vomiting, abdominal pain, fruity breath, and confusion.

Choice B reason: Metabolic alkalosis is a condition where the blood pH is higher than normal, due to an excess of bases or a loss of acids in the body. Jo is not likely to develop metabolic alkalosis, because of the high blood glucose level. Metabolic alkalosis can be caused by conditions such as vomiting, diuretic use, or excessive antacid intake, which can increase the bicarbonate level or decrease the chloride level in the blood. These conditions are not related to Jo's diabetes.

Choice C reason: Respiratory acidosis is a condition where the blood pH is lower than normal, due to an accumulation of carbon dioxide in the body. Jo is not prone to developing respiratory acidosis, because of the high blood glucose level. Respiratory acidosis can be caused by conditions that impair the lung function, such as asthma, chronic obstructive pulmonary disease (COPD), or pneumonia, which can reduce the ventilation and increase the carbon dioxide level in the blood. These conditions are not related to Jo's diabetes.

Choice D reason: Respiratory alkalosis is a condition where the blood pH is higher than normal, due to a loss of carbon dioxide in the body. Jo is not susceptible to developing respiratory alkalosis, because of the high blood glucose level. Respiratory alkalosis can be caused by conditions that increase the breathing rate, such as anxiety, fever, or hyperventilation, which can reduce the carbon dioxide level in the blood. These conditions are not related to Jo's diabetes.

Choice A reason: Last eye examination was 18 months ago is not a finding that requires immediate attention from the health care provider. However, the nurse should remind the patient of the importance of regular eye examinations, as diabetes can increase the risk of eye problems, such as cataracts, glaucoma, and diabetic retinopathy. The American Diabetes Association (ADA) recommends that patients with type 2 diabetes have a comprehensive eye examination at least once every two years¹.

Choice B reason: Patient states they are scheduled for a CT scan with contrast dye the next day is a finding that should be promptly discussed with the health care provider. Metformin is a medication that lowers the blood glucose level by reducing the liver's production of glucose and increasing the cells' sensitivity to insulin. Metformin can interact with contrast dye, which is a substance that is injected into the veins to enhance the visibility of organs and tissues in imaging tests, such as CT scans. Contrast dye can impair the kidney function and increase the risk of lactic acidosis, a rare but serious condition where the blood becomes too acidic due to the accumulation of lactic acid. Lactic acidosis can cause symptoms such as nausea, vomiting, abdominal pain, muscle weakness, and breathing difficulties. To prevent this complication, the ADA recommends that patients stop taking metformin at the time of or before the imaging procedure, and resume it 48 hours after the procedure, only if the kidney function is normal².

Choice C reason: Hemoglobin A1C level is 7.9% is not a finding that needs urgent discussion with the health care provider. Hemoglobin A1C is a test that measures the average blood glucose level over the past two to three months. It reflects how well the diabetes is controlled over time. The ADA recommends that most patients with type 2 diabetes aim for a hemoglobin A1C level of less than 7%, as this can reduce the risk of diabetes complications, such as heart disease, kidney disease, nerve damage, and eye damage. A hemoglobin A1C level of 7.9% indicates that the patient's blood glucose level is slightly above the target range, and may need some adjustment in the medication, diet, or exercise plan. However, this is not an emergency situation, and the nurse can review the patient's self-monitoring records, medication adherence, and lifestyle factors, and provide education and support as needed.

Choice D reason: Patient has questions about the prescribed diet is not a finding that warrants immediate communication with the health care provider. However, the nurse should address the patient's questions and concerns, and provide clear and consistent information about the dietary recommendations for type 2 diabetes. A healthy diet for type 2 diabetes should include a variety of foods, such as vegetables, fruits, whole grains, lean proteins, low-fat dairy, and healthy fats. The patient should also limit the intake of added sugars, refined carbohydrates, saturated fats, trans fats, and sodium. The nurse can help the patient plan their meals and snacks, and use tools such as carbohydrate counting, portion control, or the plate method to balance their food choices and blood glucose levels..