A client is concerned about the potential complications of Osteosarcoma and asks the nurse what to watch out for.
Which complication should the nurse mention as a significant concern for Osteosarcoma patients?

Choice A rationale:

Genetic predisposition, such as Li-Fraumeni syndrome, can increase the risk of Osteosarcoma.

Rationale: Li-Fraumeni syndrome is a hereditary condition characterized by a mutation in the TP53 tumor suppressor gene.

This gene normally helps regulate cell growth and prevent the formation of tumors.

Individuals with Li-Fraumeni syndrome have an increased risk of developing various cancers, including Osteosarcoma.

Therefore, the statement is accurate in identifying a genetic predisposition as a risk factor for Osteosarcoma.

Choice B rationale:

Osteosarcoma primarily affects the short bones, such as the wrist and ankle bones.

Rationale: This statement is not accurate.

Osteosarcoma typically affects the long bones, such as the arms (humerus), legs (femur and tibia), and pelvis.

It rarely occurs in short bones like the wrist and ankle bones.

Choice C rationale:

Exposure to low-dose radiation is a significant risk factor for Osteosarcoma.

Rationale: This statement is accurate.

Exposure to ionizing radiation, even at low doses, is a known risk factor for the development of Osteosarcoma.

It is particularly relevant in cases where individuals have received radiation therapy for other medical conditions.

Choice D rationale:

Individuals with Paget's disease have a decreased risk of developing Osteosarcoma.

Rationale: This statement is not accurate.

Paget's disease of the bone is actually associated with an increased risk of Osteosarcoma.

Paget's disease involves abnormal bone remodeling, which can create an environment conducive to the development of Osteosarcoma, although it is still a relatively rare complication.

Choice A rationale:

"To perform limb-sparing surgery." Chemotherapy is administered before surgery (neoadjuvant chemotherapy) to shrink the tumor and make limb-sparing surgery possible in cases of Osteosarcoma.

The primary goal is to reduce the size of the tumor and improve the chances of successful surgical removal while preserving the affected limb.

Choice C rationale:

"To remove the palpable mass." While surgery is intended to remove the palpable mass, chemotherapy is not given for the sole purpose of mass removal.

Chemotherapy is used as part of a multimodal treatment approach to target cancer cells systemically and reduce the tumor's size before surgery.

Choice D rationale:

"To administer radiation therapy." Chemotherapy is not the primary treatment for administering radiation therapy in Osteosarcoma cases.

Radiation therapy is typically considered when there is residual disease after surgery or in cases where surgery is not possible.