A client with asthma is exposed to a trigger and has an asthma attack within 30 minutes of the exposure. The client uses their albuterol inhaler as prescribed and experiences relief of symptoms. Six hours later, the client's asthma symptoms return. Which of the following is true about the late-phase response of asthma?

The late-phase response occurs due to an influx of additional inflammatory cells

The symptoms of the late-phase response tend to respond better to a rescue inhaler than the symptoms of the early-phase response

The late-phase response occurs because the client did not use their rescue inhaler properly

The late-phase response only occurs if the client continues to be exposed to their trigger after the initial attack

Answer and Explanation

The Correct Answer is A

A.   The late-phase response in asthma is characterized by a delayed and prolonged inflammatory reaction that can occur 4 to 6 hours after exposure to a trigger. It involves the recruitment of additional inflammatory cells, such as eosinophils and T cells, which contribute to ongoing airway inflammation, increased mucus production, and bronchoconstriction. This phase often leads to a return of symptoms or worsening of symptoms after the initial relief provided by a rescue inhaler.
B.   The late-phase response does not typically respond as well to rescue inhalers (such as albuterol) as the early-phase response does. Rescue inhalers are primarily effective for the immediate, bronchospastic component of asthma (early-phase response).
C.   The late-phase response occurs as part of the natural progression of asthma inflammation and is not necessarily related to improper use of a rescue inhaler. Even with proper use of a rescue inhaler, the late-phase response can still occur due to the underlying inflammatory processes.
D.   The late-phase response can occur even if the trigger is no longer present. It is related to the ongoing inflammatory process rather than continued exposure to the trigger. Although continued exposure to triggers can exacerbate symptoms, the late-phase response can still occur independently of further exposure.

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Correct Answer is D

Explanation

A. Pyridostigmine is primarily used in the treatment of myasthenia gravis, a different autoimmune neuromuscular disorder characterized by weakness of voluntary muscles. It works by inhibiting the

enzyme acetylcholinesterase, which increases the levels of acetylcholine at neuromuscular junctions, thereby improving muscle strength. It is not used for treating multiple sclerosis.
B. Levodopa-carbidopa is commonly used to treat Parkinson’s disease. Levodopa is converted to dopamine in the brain, and carbidopa prevents levodopa from being converted into dopamine before it reaches the brain. This combination helps manage the motor symptoms of Parkinson’s disease. It is not used for multiple sclerosis.
C. Riluzole is used primarily for the treatment of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons. It works by reducing the release of glutamate, a neurotransmitter that can be toxic to nerve cells. Riluzole is not used for multiple sclerosis.
D. Interferon-beta is a disease-modifying therapy used in the treatment of multiple sclerosis. It works by modulating the immune system to reduce the frequency and severity of MS relapses. Interferon-beta can help slow the progression of disability and reduce the number of new lesions seen on MRI scans.

A. Multiple sclerosis (MS) B. Myasthenia gravis (MG) C. Guillain-Barre syndrome (GBS) D. Systemic lupus erythematosus (SLE)

Correct Answer is D

Explanation

A. MS is an autoimmune disorder affecting the central nervous system, not the kidneys.
B. MG is an autoimmune disorder affecting the neuromuscular junction, not the kidneys.
C. GBS is an autoimmune disorder affecting the peripheral nervous system, not the kidneys.
D. SLE is a systemic autoimmune disorder that can affect multiple organs, including the kidneys. Glomerulonephritis is a common complication of SLE.

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Which medication is commonly used in the treatment of multiple sclerosis?

Correct Answer is D

Explanation

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Correct Answer is D

Explanation

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