A healthcare professional is educating a patient about asthma. The professional states that good control is necessary due to which pathophysiologic process?

Norepinephrine causes bronchial smooth muscle contraction and mucus secretion but it also causes high blood pressure

Uncontrolled inflammation leads to increased bronchial hyperresponsiveness and eventual scarring

Immunoglobulin G causes smooth muscle contraction which will eventually weaken the respiratory muscles

The release of epinephrine leads to development of cardiac dysrhythmias.

Answer and Explanation

The Correct Answer is B

A. Norepinephrine causes bronchial smooth muscle contraction and mucus secretion but it also causes high blood pressure: This statement is misleading in the context of asthma. Norepinephrine primarily acts on alpha and beta receptors, influencing blood pressure and bronchodilation but is not the main mediator in asthma pathophysiology. The focus should be on inflammation and airway responsiveness.

B. Uncontrolled inflammation leads to increased bronchial hyperresponsiveness and eventual scarring: This statement accurately describes the pathophysiologic process in asthma. Persistent inflammation in asthma can cause increased bronchial hyperresponsiveness, leading to airway narrowing and potential long-term remodeling and scarring of the airways if not controlled. Effective management is essential to prevent these adverse outcomes.

C. Immunoglobulin G causes smooth muscle contraction which will eventually weaken the respiratory muscles: Immunoglobulin E (IgE) is primarily involved in allergic reactions and asthma, and it does not directly cause smooth muscle contraction that weakens respiratory muscles.

D. The release of epinephrine leads to development of cardiac dysrhythmias: While epinephrine can have cardiovascular effects, including increased heart rate and potential for dysrhythmias, this is not directly relevant to the pathophysiology of asthma. The focus in asthma management is on controlling airway inflammation and bronchoconstriction rather than on cardiac issues.

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Correct Answer is D

Explanation

A. Cardiac failure: While cardiac failure can lead to changes in heart function, it does not directly cause an acquired murmur. Murmurs are typically due to valvular or structural abnormalities rather than being a direct consequence of heart failure.

B. Coronary artery disease (CAD): CAD can lead to ischemic heart disease and may contribute to heart failure but is not typically associated with the development of an acquired murmur. It does not directly create new murmurs; rather, it can exacerbate existing heart conditions.

C. Congenital malformation: Congenital malformations are structural heart defects present at birth and are classified as congenital causes of murmurs rather than acquired. These murmurs result from anatomical abnormalities rather than changes occurring after birth.

D. Rheumatic fever: Rheumatic fever is an acquired condition that can cause damage to the heart valves, leading to the development of valvular insufficiency or stenosis. These changes can produce an acquired murmur as a result of the inflammation and scarring of the heart valves following the infection.

A. It does not remain dormant but some host defenses can kill the bacteria B. Virulence factors in the baciilli weaken over time leading to apoptosis C. The bacilli can become isolated within tubercles in the lungs, possibly encapsulated D. Macrophages attack and phagocytize new areas of infection

Correct Answer is C

Explanation

A. It does not remain dormant but some host defenses can kill the bacteria: While the immune system can kill some of the Mycobacterium tuberculosis bacilli, in many cases, the bacteria evade complete eradication and persist in a dormant state within the lungs. This does not mean the infection is fully eliminated, as it can reactivate later.

B. Virulence factors in the bacilli weaken over time, leading to apoptosis: Mycobacterium tuberculosis does not naturally lose its virulence over time. Instead, it can persist in a latent state due to immune containment, not because of a reduction in its ability to cause disease.

C. The bacilli can become isolated within tubercles in the lungs, possibly encapsulated: In latent tuberculosis, the immune system walls off the bacilli within granulomas (tubercles), preventing active disease. These granulomas may be encapsulated with fibrous tissue, restricting bacterial growth and spread. The bacteria remain dormant but can reactivate if the immune system weakens.

D. Macrophages attack and phagocytize new areas of infection: While macrophages do play a role in the immune response to tuberculosis, they are often unable to completely eradicate the bacilli. Instead, the bacteria can survive within macrophages and trigger the formation of granulomas, which help contain but not eliminate the infection.

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A healthcare professional is educating a patient about asthma. The professional states that good control is necessary due to which pathophysiologic process?

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Naxlex Comprehensive Predictor Exams

Which condition is a cause of an acquired murmur?

Correct Answer is D

Explanation

A fellow student asks you to explain how tuberculosis (TB) can remain dormant in some people. What explanation will you give?

Correct Answer is C

Explanation

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