A nurse in an outpatient mental health setting is collecting a health history from a client who is taking paroxetine for depression. The client reports to the nurse that he also takes herbal supplements. The nurse should advise the client that which of the following supplements interacts adversely with paroxetine?

Echinacea

Ginkgo

St. John's Wort

Saw palmetto

Answer and Explanation

The Correct Answer is C

Choice A reason: Echinacea is used for immune support and has no significant interaction with paroxetine, an SSRI that increases serotonin by inhibiting reuptake. Echinacea’s effects on cytokine production do not alter serotonin metabolism or CYP450 enzymes, which paroxetine relies on for clearance, making it a safe supplement in this context.

Choice B reason: Ginkgo enhances cerebral blood flow but has minimal interaction with paroxetine. It may affect platelet aggregation, but paroxetine’s serotonin reuptake inhibition is primarily metabolized via CYP2D6, unaffected by ginkgo’s mechanisms. No significant pharmacodynamic or pharmacokinetic interactions occur, making this supplement safe for concurrent use with paroxetine.

Choice C reason: St. John’s Wort induces CYP3A4 and P-glycoprotein, accelerating paroxetine metabolism, an SSRI reliant on CYP2D6. This reduces paroxetine’s efficacy, lowering serotonin levels and risking treatment failure for depression. It also increases serotonin syndrome risk due to additive serotonergic effects, making it a critical interaction to avoid.

Choice D reason: Saw palmetto, used for prostate health, has no significant interaction with paroxetine. It primarily affects androgen pathways, not serotonin metabolism or CYP2D6, which paroxetine uses for clearance. No pharmacodynamic or pharmacokinetic conflicts arise, making saw palmetto a safe supplement for clients taking paroxetine for depression.

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Correct Answer is C

Explanation

Choice A reason: Administering 2 teaspoons (10 mL) would deliver 500 mg of Amoxicillin, as the concentration is 250 mg/5 mL, and 1 teaspoon equals 5 mL. This dose is double the prescribed 250 mg, risking overdose. Amoxicillin overdose can cause gastrointestinal distress or, in rare cases, renal toxicity, making this choice scientifically inappropriate for the prescribed dose.

Choice B reason: Giving 3 teaspoons (15 mL) would deliver 750 mg of Amoxicillin, far exceeding the prescribed 250 mg dose. The concentration is 250 mg/5 mL, so 15 mL contains three times the required amount. This could lead to adverse effects like diarrhea or allergic reactions, as excessive antibiotic levels disrupt gut flora and increase toxicity risks.

Choice C reason: One teaspoon (5 mL) delivers exactly 250 mg of Amoxicillin, matching the prescribed dose, as the concentration is 250 mg/5 mL. This ensures therapeutic efficacy for treating infections like otitis media in children, maintaining serum levels within the therapeutic range (MIC for common pathogens like Streptococcus pneumoniae), minimizing side effects, and adhering to pediatric dosing guidelines.

Choice D reason: Four teaspoons (20 mL) would deliver 1000 mg of Amoxicillin, four times the prescribed dose. At 250 mg/5 mL, this excessive dose risks severe side effects, including nephrotoxicity or hepatotoxicity, and disrupts microbial balance, potentially causing antibiotic resistance. This is scientifically inappropriate, as it deviates significantly from the therapeutic dose for an 8-year-old.

A. 0.5 to 1.2 mEq/L B. 10 to 50 mEq/L C. 0.1 to 1 mEq/L D. 50 to 100 mEq/L

Correct Answer is A

Explanation

Choice A reason: Lithium’s therapeutic range for maintenance in bipolar disorder is 0.5–1.2 mEq/L, balancing mood stabilization via sodium channel modulation and neuroprotection with safety. This range minimizes toxicity risks like tremors or renal damage, ensuring effective serotonin and dopamine regulation while maintaining safe serum concentrations.

Choice B reason: A 10–50 mEq/L lithium level is far above the therapeutic range, causing severe toxicity, including seizures or coma, due to excessive sodium channel inhibition and neuronal dysfunction. This range is lethal, disrupting renal and neurological function, making it scientifically inaccurate for maintenance or safety.

Choice C reason: A 0.1–1 mEq/L range is partially subtherapeutic, as levels below 0.5 mEq/L are ineffective for mood stabilization in bipolar disorder. Lithium requires 0.5–1.2 mEq/L to modulate sodium channels and serotonin, making this range inadequate for therapeutic efficacy while still posing minor toxicity risks.

Choice D reason: A 50–100 mEq/L lithium level is exponentially above safe limits, causing fatal toxicity, including renal failure and neurological damage, due to extreme sodium channel disruption. This range is not viable for maintenance, as it far exceeds the therapeutic window, leading to severe neurobiological and systemic harm.

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Naxlex Comprehensive Predictor Exams

Bobby is an 8-year-old patient who is to receive Amoxicillin 250 mg every 8 hours. You have 250 mg/5 mL. How many teaspoons will you tell his mother to administer every 8 hours?

Correct Answer is C

Explanation

Identify the serum lithium level for maintenance and safety.

Correct Answer is A

Explanation

A 68-year-old client who is hospitalized with pneumonia is disoriented and confused 3 days after admission. Which information indicates that the client is experiencing delirium rather than dementia?

Which of the following typifies the speech of a person in the acute phase of mania?

A nurse is reviewing routine laboratory values for several clients who are taking lithium carbonate. Which of the following clients should the nurse assess further for findings indicating lithium toxicity?

Which nursing diagnosis should be most useful for clients with anxiety disorders for whom the following defining characteristics have been identified: avoidance, poor concentration, nightmares, hypervigilance, exaggerated startle response, detachment, numbing, and flashbacks?

A nurse is planning care for a client who is to undergo electroconvulsive therapy (ECT). Which of the following actions should the nurse include in the plan?

A client with advanced Alzheimer's disease keeps searching the unit for her mother who died many years ago. How should the nurse respond?