A nurse is assessing a client's risk factors for chronic renal failure. Which medical condition should the nurse recognize as a significant risk factor for kidney disease?

A. Incorrect. Excess production of calcium in the body is not a typical cause of bone pain in chronic renal failure.

B. Correct. Chronic renal failure can lead to impaired phosphorus excretion, resulting in elevated levels of phosphorus in the blood. High phosphorus levels can lead to bone demineralization, weakening the bones and causing bone pain.

C. Incorrect. While some medications used in the management of chronic renal failure may have side effects, frequent bone pain is not commonly associated with these medications.

D. Incorrect. Kidney dysfunction in chronic renal failure does not typically lead to low levels of calcium in the bones. Instead, it can lead to abnormalities in phosphorus levels, which affect bone health.

A. Incorrect. Peripheral edema and weight gain are more commonly associated with fluid retention in later stages of chronic renal failure when the kidneys are unable to effectively remove excess fluids from the body.

B. Incorrect. Frothy urine and increased urination may indicate proteinuria, a condition where excessive protein is excreted in the urine. While proteinuria can be a symptom of kidney dysfunction, it is not an early symptom.

C. Incorrect. Hypertension and headache can be associated with chronic renal failure, but they are not specific to early stages of kidney dysfunction.

D. Correct. Fatigue and decreased appetite are early clinical manifestations of kidney dysfunction in chronic renal failure. The kidneys play a vital role in filtering waste products and toxins from the blood, and when kidney function is compromised, it can lead to a buildup of waste products in the body, causing fatigue and decreased appetite.