A nurse is caring for an infant whose screening test reveals a potential diagnosis of sickle cell disease. Which of the following tests should the nurse expect the provider to prescribe to distinguish whether the infant has sickle cell disease or sickle cell trait?

A. Both parents are carriers of the CF gene: Cystic fibrosis follows an autosomal recessive inheritance pattern, meaning both parents must carry one copy of the defective gene, even if they do not have the disease themselves. The child inherits one copy of the defective gene from each parent to develop CF.

B. The inheritance pattern is multifactorial: CF is not a multifactorial disease; it follows a clear recessive genetic inheritance pattern.

C. The result is probably a genetic mutation: CF is caused by a genetic mutation, but this mutation is inherited from both parents. It is not usually a spontaneous mutation unless it occurs in the parental genetic material, which is rare.

D. Only one parent carries the CF gene: For the child to inherit CF, both parents must be carriers of the gene. If only one parent carries the gene, the child would be a carrier, not affected by the disease.

A. Hoarseness: Hoarseness is a common symptom of croup and is usually not an immediate concern unless accompanied by other severe symptoms.

B. Barky cough: A barky cough is characteristic of croup and is not an indication of immediate concern unless it worsens.

C. Drooling: Drooling can be a sign of respiratory distress and difficulty swallowing, which can indicate a worsening condition such as epiglottitis, a more serious infection that can occur with croup. Drooling is a red flag and requires immediate medical attention.

D. Paroxysmal attacks of laryngeal spasm at night: Paroxysmal attacks (episodes of severe coughing or difficulty breathing) are typical of croup, especially at night, but are usually self-limited and not an immediate cause for concern unless severe.