A nurse is educating a client about the etiology of cystic fibrosis (CF). Which statement by the client accurately describes the genetic basis of CF?
"CF is caused by a single gene mutation, which can be inherited from one parent."
"CF results from a combination of genetic and environmental factors."
"CF occurs due to an X-linked genetic mutation passed from mother to daughter."
"CF is primarily caused by exposure to respiratory pathogens during infancy."
The Correct Answer is A
A) Correct. CF is primarily caused by mutations in a single gene, the CFTR gene, and it can be inherited from one parent, resulting in a carrier state, or from both parents for the disease to manifest.
B) Incorrect. While genetic factors are the primary cause of CF, environmental factors can exacerbate symptoms but are not the root cause.
C) Incorrect. CF is not an X-linked genetic disorder; it follows an autosomal recessive pattern of inheritance.
D) Incorrect. CF is not caused by exposure to respiratory pathogens during infancy; it is primarily a genetic disorder.
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Correct Answer is D
Explanation
A) Incorrect. Hypertension is not typically associated with CF.
B) Incorrect. Hypoglycemia is not a common manifestation of CF.
C) Incorrect. Chronic diarrhea is not a common symptom of CF.
D) Correct. CF is characterized by thick, sticky mucus that can lead to chronic respiratory infections, making this a key clinical manifestation to monitor.
Correct Answer is C
Explanation
A) Incorrect. CF is an autosomal recessive genetic disorder, meaning that both copies of the CFTR gene must carry a mutation for the condition to manifest.
B) Incorrect. CF is not caused by dominant genetic mutations.
C) Correct. CF results from inheriting two recessive genetic mutations, one from each parent, leading to defective CFTR protein function.
D) Incorrect. CF is primarily a genetic disorder with well-established genetic mutations associated with its development.
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