A nurse is educating a group of travelers who are going to a region where malaria is endemic.
Which of the following antimalarial drugs should the nurse recommend for prophylaxis? (Select all that apply.).

These are the antimalarial drugs that are recommended for prophylaxis by the CDC and other sources.

They are effective against the malaria parasites that are resistant to chloroquine and primaquine, which are the other two options.

Choice A is wrong because chloroquine is not effective in areas where chloroquine resistance is present, which is most of the malaria-endemic regions.

Choice B is wrong because primaquine is not used for prophylaxis, but for radical cure of vivax and ovale malaria.It also requires a test for glucose-6-phosphate dehydrogenase (G6PD) deficiency before use, as it can cause hemolysis in people with this condition.

Choice C is correct because mefloquine is a suppressive prophylactic that can be used in areas with chloroquine resistance.

Anaphylaxis is a severe allergic reaction that can be life-threatening and requires immediate medical attention.Penicillin is one of the most common causes of anaphylaxis.Symptoms of anaphylaxis include difficulty breathing, swelling of the face, throat, or tongue, hives, itching, low blood pressure, and shock.

Choice A is wrong because hypokalemia (low potassium levels in the blood) is not a common or serious side effect of penicillin therapy.Hypokalemia can cause muscle weakness, cramps, irregular heartbeat, and fatigue.

Choice B is wrong because hyperglycemia (high blood sugar levels) is not a common or serious side effect of penicillin therapy.Hyperglycemia can cause thirst, frequent urination, blurred vision, and headaches.

Choice D is wrong because constipation is not a common or serious side effect of penicillin therapy.Constipation can cause abdominal pain, bloating, and difficulty passing stools.