A nurse is caring for a client who is receiving gentamicin, an aminoglycoside antibiotic, for a severe infection.
The nurse should monitor the client for which adverse effects of this drug? (Select all that apply.)

Ototoxicity

Nephrotoxicity

Hepatotoxicity

Neuromuscular blockade

Thrombocytopenia.

Answer and Explanation

Correct Answer : A,B

Gentamicin is an aminoglycoside antibiotic that can cause ototoxicity (damage to the inner ear) and nephrotoxicity (damage to the kidneys) as serious side effects. These effects may be irreversible and can occur even at therapeutic doses. Therefore, the nurse should monitor the client’s hearing, balance, urine output, and blood tests for kidney function while on this drug.

Choice C is wrong because gentamicin does not cause hepatotoxicity (damage to the liver).

This is more common with other antibiotics such as isoniazid or rifampin.

Choice D is wrong because gentamicin does not cause neuromuscular blockade (paralysis of muscles).

This is more common with other aminoglycosides such as neomycin or tobramycin.

Choice E is wrong because gentamicin does not cause thrombocytopenia (low platelet count).

This is more common with other drugs such as heparin or sulfonamides.

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Correct Answer is B

Explanation

A superinfection is defined as an infection that comes second to an initial infection and is often caused by the elimination of normal flora by an antibiotic.

Normal flora are the microorganisms that normally live in the human body and help prevent the growth of harmful pathogens.

When an antibiotic kills the normal flora, it creates an opportunity for other microorganisms to overgrow and cause a new infection.

Choice A is wrong because a resistant infection is an infection that does not respond to an antibiotic due to the presence of resistant bacteria.

Resistance can occur when bacteria mutate or acquire genes that make them able to survive the antibiotic.

Choice C is wrong because a nosocomial infection is an infection that is acquired in a hospital or health care setting.

Nosocomial infections can be caused by various factors, such as exposure to contaminated equipment, poor hygiene practices, or transmission from other patients or staff.

Choice D is wrong because an allergic reaction is an immune response to a foreign substance that is not harmful.

Allergic reactions can occur when a person is sensitive to an antibiotic or any other drug.

Symptoms of an allergic reaction may include rash, itching, swelling, or difficulty breathing.

A. Urticaria B. Bronchospasm C. Anaphylaxis D. Stevens-Johnson syndrome E. Angioedema.

Correct Answer is ["A","B","C","E"]

Explanation

Cefazolin can cause serious or life-threatening allergic reactions in some patients, especially those with a history of penicillin allergy.The most common allergic reactions to cefazolin are immediate reactions, such as anaphylaxis, urticaria, bronchospasm, and angioedema.These reactions usually occur within one hour of the drug administration and may involve symptoms such as rash, itching, swelling, difficulty breathing, low blood pressure, and shock.Immediate reactions are mediated by immunoglobulin E (IgE) antibodies that bind to the drug and trigger the release of inflammatory mediators from mast cells and basophils.

Choice D is wrong because Stevens-Johnson syndrome is not a typical allergic reaction to cefazolin.

Stevens-Johnson syndrome is a rare and severe skin reaction that can be caused by various drugs, infections, or autoimmune diseases.

It involves blistering and peeling of the skin and mucous membranes, fever, malaise, and eye inflammation.

Stevens-Johnson syndrome is not mediated by IgE antibodies, but by other immune mechanisms that damage the skin cells.

Cefazolin is not known to cause Stevens-Johnson syndrome, although other cephalosporins have been reported to do so in rare cases.

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A nurse is caring for a client who is receiving gentamicin, an aminoglycoside antibiotic, for a severe infection. The nurse should monitor the client for which adverse effects of this drug? (Select all that apply.)

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

The development of a new infection as a result of the elimination of normal flora by an antibiotic is referred to as what?

Correct Answer is B

Explanation

A patient is receiving cefazolin, a first-generation cephalosporin, for a surgical prophylaxis. The nurse should assess the patient for which of the following possible allergic reactions? (Select all that apply.)

Correct Answer is ["A","B","C","E"]

Explanation

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A nurse is caring for a client who is receiving gentamicin, an aminoglycoside antibiotic, for a severe infection.
The nurse should monitor the client for which adverse effects of this drug? (Select all that apply.)