A nurse is preparing to administer antiviral therapy.
The nurse integrates knowledge of this therapy, administering the drugs cautiously to clients with which of the following?

Hepatic impairment.

Renal impairment.

Diabetes.

Hypertension.

Answer and Explanation

The Correct Answer is A

Choice A rationale:

Antiviral drugs are metabolized in the liver, and hepatic impairment can affect the metabolism and elimination of these drugs. Therefore, the nurse should administer antiviral therapy cautiously to clients with hepatic impairment to prevent potential drug toxicity. Hepatic impairment can alter the pharmacokinetics of antiviral drugs, leading to increased drug levels in the bloodstream.

Choice B rationale:

Renal impairment is not typically a contraindication for antiviral therapy. While some medications may require dose adjustments in patients with renal impairment, it is not a general concern for antiviral drugs. The primary organ responsible for the metabolism of antiviral drugs is the liver.

Choice C rationale:

Diabetes and hypertension are chronic medical conditions that are not directly related to the administration of antiviral therapy. These conditions do not significantly impact the pharmacokinetics or pharmacodynamics of antiviral drugs. Therefore, they are not primary factors to consider when administering antiviral therapy.

Choice D rationale:

Hypertension, like diabetes, is not directly related to the administration of antiviral therapy. Antiviral drugs primarily interact with the liver's metabolic pathways, and hypertension does not have a significant impact on drug metabolism.

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Correct Answer is D

Explanation

Choice A rationale:

Lymphoma is not a known adverse effect of aspirin use. Reye's syndrome, a rare but severe condition, is associated with aspirin use in children recovering from viral infections such as chickenpox or influenza. Therefore, it is important to be alert to the development of Reye's syndrome when aspirin is administered to a child with these infections.

Choice B rationale:

Angioneurotic edema is not a typical adverse effect of aspirin use in children with chickenpox. Reye's syndrome is the more relevant concern.

Choice C rationale:

Acute renal failure is not a direct result of aspirin use for fever in children. The primary concern in this context is Reye's syndrome, which affects the brain and liver.

A. Protease inhibitors. B. Reverse transcriptase inhibitors. C. Nonnucleoside reverse transcriptase inhibitors. D. Integrase inhibitors.

Correct Answer is A

Explanation

Choice A rationale:

Protease inhibitors are a category of antiretroviral drugs used in the treatment of HIV. They work by affecting an enzyme called protease, which is necessary for the maturation of new viral particles. By inhibiting protease, these drugs prevent the formation of mature, infectious HIV particles.

Choice B rationale:

Reverse transcriptase inhibitors, including both nucleoside and non-nucleoside variants, target the enzyme reverse transcriptase. This enzyme is involved in the conversion of HIV RNA into DNA, an essential step in the viral life cycle. However, it's not about preventing the maturation of new viral particles, as mentioned in the question.

Choice C rationale:

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) also inhibit the reverse transcriptase enzyme, but they do so differently than protease inhibitors. While they are vital in HIV treatment, they do not specifically target the maturation of viral particles.

Choice D rationale:

Integrase inhibitors target the enzyme integrase, which is involved in the integration of viral DNA into the host cell's DNA. This step is crucial in the HIV life cycle, but it's not related to the maturation of new viral particles.

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A nurse is preparing to administer antiviral therapy.The nurse integrates knowledge of this therapy, administering the drugs cautiously to clients with which of the following?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

The parents of a child who is recovering from chickenpox tell the nurse that they gave the child aspirin for his fever.The nurse would be alert to the development of which of the following?

Correct Answer is D

Explanation

A nursing instructor is describing the different categories of antiretroviral agents used in treatment for HIV infection.The instructor determines that the teaching was successful when the students identify which category as affecting an enzyme so that new viral particles cannot mature?

Correct Answer is A

Explanation

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A nurse is preparing to administer antiviral therapy.
The nurse integrates knowledge of this therapy, administering the drugs cautiously to clients with which of the following?