A nurse is discussing the possible adverse reactions that may occur with antineoplastic therapy.
Which of the following would the nurse discuss as examples of long-term adverse reactions?

Choice A rationale:

Antihelminthic therapy does not need to be administered cautiously in clients who have cardiac disease unless there are specific contraindications or drug interactions that would necessitate caution. The primary concern in these cases would be ensuring that the chosen antihelminthic drug does not interact adversely with the medications used to manage the client's cardiac condition.

Choice B rationale:

Antihelminthic therapy should be administered cautiously in clients with hepatic impairment. The liver plays a significant role in drug metabolism and elimination. Clients with hepatic impairment may have altered drug metabolism, which can affect the pharmacokinetics of antihelminthic drugs. Therefore, caution is needed to adjust the dosing and monitor for potential side effects in clients with compromised liver function.

Choice C rationale:

Clients with diabetes do not typically require cautious administration of antihelminthic therapy solely due to their diabetes. However, it is essential to consider potential drug interactions with antidiabetic medications that the client may be taking. The primary concern would be ensuring that the antihelminthic drug does not interfere with diabetes management.

Choice D rationale:

Clients with respiratory disorders do not necessarily require cautious administration of antihelminthic therapy based solely on their respiratory condition. However, it is crucial to consider potential drug interactions with medications used to manage the respiratory disorder. Antihelminthic drugs are primarily targeted at parasitic infections and may not directly impact respiratory conditions.

Choice A rationale:

Administering a combination of drugs in TB treatment is not primarily aimed at preventing the incidence of liver dysfunction. The combination therapy's main objective is to address the complex nature of Mycobacterium tuberculosis infections and the potential development of antibiotic resistance.

Choice B rationale:

The nurse should explain that the primary reason for administering a combination of drugs is to slow down bacterial resistance. When TB is treated with a single drug, the bacteria can quickly develop resistance to that drug. Using a combination of drugs with different mechanisms of action makes it more difficult for the bacteria to develop resistance. This is a fundamental principle in the treatment of TB.

Choice C rationale:

Slowing the body's resistance to medication is not a goal in TB treatment. The focus is on preventing the development of resistance in the bacteria, not the body's response to the medication.

Choice D rationale:

While TB treatment aims to prevent the further spread of the disease, the primary reason for using a combination of drugs is to address bacterial resistance. Preventing the spread of TB is an important secondary benefit of effective treatment.