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Harry Eastlack died from a condition where his connective tissues and muscles turned to bone. What did he die from?

A.

osteogenesis imperfecta

B.

osteopetrosis

C.

chondroidal ossification

D.

fibrodysplasia ossificans progressiva

E.

osteoarthritis

Answer and Explanation

The Correct Answer is D

A. osteogenesis imperfecta
This is brittle bone disease, caused by defective collagen, not muscle turning into bone.

B. osteopetrosis
This is a rare condition involving overly dense bones due to osteoclast failure, not soft tissue ossification.

C. chondroidal ossification
This is not a recognized clinical condition. Ossification of cartilage does occur in development but doesn’t describe Harry's case.

D. fibrodysplasia ossificans progressiva (FOP)
FOP is a rare genetic disorder where soft connective tissues such as muscles, tendons, and ligaments turn into bone, progressively restricting movement and ultimately leading to complications that may be fatal.

E. osteoarthritis
This involves cartilage degeneration at joints due to wear and tear-not ectopic bone formation in soft tissues.


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Related Questions

Correct Answer is D

Explanation

A. parathyroid hormone is released, decreasing osteoclast activity
Parathyroid hormone (PTH) is released when calcium levels are low, not high. Also, PTH increases, not decreases, osteoclast activity to raise serum calcium.

B. calcitonin hormone is released, increasing osteoclast activity
Calcitonin is released during high calcium levels, but it works to decrease osteoclast activity, not increase it.

C. parathyroid hormone is released, increasing osteoclast activity
This would occur in response to low calcium, which is not the case here. Mary has excess calcium.

D. calcitonin hormone is released, decreasing osteoclast activity
With elevated calcium levels, the thyroid gland releases calcitonin, which works to inhibit osteoclasts to reduce calcium release from bone, helping to restore balance.

Correct Answer is B

Explanation

A. vitamin A
Vitamin A plays a role in bone remodeling, but excess vitamin A can cause bone fragility. It’s not the first recommendation in cases of brittle bones.

B. vitamin D
Vitamin D helps the body absorb calcium from the digestive tract. A deficiency can lead to osteomalacia (soft bones) or osteoporosis (brittle bones), and also contributes to tooth decay.

C. vitamin C
Vitamin C is needed for collagen synthesis, which is important in bone matrix formation, but deficiency leads to scurvy, not typically brittle bones and teeth loss in this context.

D. vitamin E
Vitamin E is an antioxidant but does not have a primary role in bone or dental health.

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