The nurse suspects that a patient has polycythemia vera based on which finding in the patient's laboratory reports? Select all that apply.
One, some, or all responses may be correct.

Choice A rationale:
Increased cobalamin levels are not indicative of polycythemia vera. Polycythemia vera is characterized by an increase in the total red blood cell mass. Elevated cobalamin levels are not specific to this condition.
Choice B rationale:
Decreased histamine levels are not a diagnostic marker for polycythemia vera. Histamine levels are not typically associated with this disorder.
Choice C rationale:
Increased hemoglobin levels are a significant finding in polycythemia vera. Polycythemia vera is a disorder characterized by an abnormal increase in the number of red blood cells, leading to elevated hemoglobin levels.
Choice D rationale:
Increased red blood cell levels are a hallmark feature of polycythemia vera. The increased production of red blood cells leads to elevated red blood cell levels, which is a key diagnostic indicator for this condition.

Choice A rationale:

A low level of hepcidin would not cause a decrease in hemoglobin levels. Hepcidin regulates iron homeostasis by inhibiting the absorption of iron from the intestines and promoting its storage in cells.

Choice B rationale:

An increase in iron-binding capacity typically occurs in conditions like iron deficiency anemia, where the body tries to increase its capacity to transport iron. This would not cause a low hemoglobin level in an otherwise healthy individual.

Choice C rationale:

Aging often leads to a decrease in the efficiency of nutrient absorption, including iron. This decrease in intestinal absorption of iron can result in low hemoglobin levels in elderly individuals. It's a common cause of anemia in the elderly population.

Choice D rationale:

Erythropoietin is a hormone produced by the kidneys that stimulates the production of red blood cells. A decrease in erythropoietin secretion from the kidneys would lead to anemia, but it is not a typical effect of aging and is usually associated with kidney disease.