Which of the following describes these characteristics: eyes widely separated and have epicanthic folds, ears low set, nose broad and flat or beak-like, receding chin and many time limb defects are present.

A. Bruton's disorder: Also known as X-linked agammaglobulinemia, this is a primary immunodeficiency that results in absent or reduced B cells and recurrent bacterial infections. It does not involve distinct facial features or limb defects as described in the question.

B. SCID: Severe Combined Immunodeficiency involves profound defects in both B and T lymphocyte function, leading to severe infections early in life. It is not associated with the described craniofacial abnormalities or limb deformities.

C. Potter syndrome: This condition is caused by severe oligohydramnios, often due to bilateral renal agenesis, and leads to characteristic physical features including widely spaced eyes with epicanthic folds, low-set ears, a broad or beaked nose, a receding chin, and limb deformities.

D. Down Syndrome: While individuals with Down Syndrome often have characteristic facial features such as upslanting palpebral fissures, flat nasal bridges, and low-set ears, they typically do not have beak-like noses, receding chins, or limb defects in the way described.

A. Acute renal disease–acute glomerulonephritis: This leads to inflammation and damage of the glomerular basement membrane, impairing filtration and causing intrarenal injury. It often presents with hematuria, proteinuria, and hypertension.

B. Exposure to nephrotoxic drugs, heavy metals, and organic solvents: These substances damage renal tubules through direct toxicity or by causing crystal formation, leading to acute tubular necrosis. Common agents include aminoglycosides and contrast dyes.

C. Prolonged renal ischemia: Sustained low perfusion causes tubular cell death and sloughing, leading to obstruction and decreased GFR. It is often a progression from untreated prerenal AKI.

D. Liver failure: Liver dysfunction reduces renal perfusion and may cause hepatorenal syndrome, but this is classified as prerenal, not intrarenal, in origin. The kidneys are structurally intact but functionally impaired.