The nurse is reviewing the diagnostic evaluation for a client with suspected immunodeficiency disorder. Which finding would be consistent with a potential diagnosis of severe combined immunodeficiency (SCID)?

Explanation: The correct answer is c. Common variable immunodeficiency (CVID) is characterized by a deficiency or absence of B cells, leading to a reduced ability to produce antibodies and an increased susceptibility to infections.

Incorrect choices:

a. DiGeorge syndrome is a disorder caused by a genetic defect resulting in the underdevelopment of the thymus and parathyroid glands, leading to T cell deficiency.

b. Severe combined immunodeficiency (SCID) is a severe form of immunodeficiency that affects both B and T cells, leading to a complete absence or dysfunction of the immune system.

d. Wiskott-Aldrich syndrome is a rare X-linked genetic disorder characterized by a triad of symptoms, including eczema, low platelet count, and immunodeficiency. It primarily affects T cells and platelets, not B cells.

Explanation: The correct answer is c. Frequent and severe infections are common clinical manifestations of immunodeficiency disorders. The weakened immune system is unable to effectively defend against infections, leading to recurrent and severe infections.

Incorrect choices:

a. Severe allergic reactions are more characteristic of allergies or hypersensitivity disorders, not immunodeficiency disorders.

b. Chronic inflammation can be seen in various conditions, but it is not a specific clinical manifestation of immunodeficiency disorders.

d. Autoimmune diseases result from an overactive immune response attacking the body's own tissues, which is the opposite of immunodeficiency disorders where the immune system is weakened and unable to adequately protect against infections.