There are three key factors involved in the formation of a thrombus. What are these factors and what are they called?

A. Inflammation: Inflammation refers to the body's immune response to injury or infection and does not specifically denote a temporary deprivation of blood supply to a cell. It is characterized by redness, swelling, heat, and pain in the affected area.

B. Necrosis: Necrosis is the process of cell death that occurs when cells are irreversibly damaged, often due to a lack of blood supply or other injury. It is a consequence of prolonged ischemia rather than the temporary condition itself.

C. Infarction: Infarction refers to the death of tissue due to prolonged ischemia, resulting from an irreversible loss of blood supply. It indicates permanent damage and is not synonymous with a temporary deprivation of blood supply.

D. Ischemia: Ischemia is the term used to describe a temporary reduction in blood flow to a tissue or organ, resulting in a deficiency of oxygen and nutrients. This condition can lead to symptoms and may cause damage if prolonged, making it the correct answer for this scenario.

A. It does not remain dormant but some host defenses can kill the bacteria: While the immune system can kill some of the Mycobacterium tuberculosis bacilli, in many cases, the bacteria evade complete eradication and persist in a dormant state within the lungs. This does not mean the infection is fully eliminated, as it can reactivate later.

B. Virulence factors in the bacilli weaken over time, leading to apoptosis: Mycobacterium tuberculosis does not naturally lose its virulence over time. Instead, it can persist in a latent state due to immune containment, not because of a reduction in its ability to cause disease.

C. The bacilli can become isolated within tubercles in the lungs, possibly encapsulated: In latent tuberculosis, the immune system walls off the bacilli within granulomas (tubercles), preventing active disease. These granulomas may be encapsulated with fibrous tissue, restricting bacterial growth and spread. The bacteria remain dormant but can reactivate if the immune system weakens.

D. Macrophages attack and phagocytize new areas of infection: While macrophages do play a role in the immune response to tuberculosis, they are often unable to completely eradicate the bacilli. Instead, the bacteria can survive within macrophages and trigger the formation of granulomas, which help contain but not eliminate the infection.