Tumor markers are substances that may be detected in cells or body fluids and can provide clues to the presence, extent, and treatment response of certain neoplasms. What is an example of a tumor marker?

Choice A reason: The most obvious and common clinical manifestation of kidney stones is severe pain, often described as excruciating and colicky. This pain is typically located in the back or side, just below the ribs, and may radiate to the lower abdomen and groin. The pain occurs as the stone moves through the urinary tract, causing irritation and blockage. This intense pain is often what prompts individuals to seek medical attention and is a hallmark symptom of kidney stones.

Choice B reason: Tachycardia, or an increased heart rate, may occur as a secondary response to the severe pain caused by kidney stones, but it is not the primary clinical manifestation. Tachycardia can be a symptom of many other conditions and is not specific to kidney stones.

Choice C reason: Hypertension, or high blood pressure, is not a direct manifestation of kidney stones. While there may be some association between kidney stone disease and hypertension, the primary symptom of kidney stones is pain, not elevated blood pressure.

Choice D reason: Edema, or swelling, is not a typical clinical manifestation of kidney stones. Edema is more commonly associated with conditions such as heart failure, kidney disease, and certain vascular disorders. Kidney stones primarily cause pain and urinary symptoms rather than generalized swelling.

Choice A reason: Polydipsia refers to excessive thirst, polyuria refers to frequent urination, polyphagia refers to increased hunger, weight loss often occurs despite an increased appetite, and fatigue is a common symptom due to the body's inability to properly use glucose for energy. These symptoms are classic early signs of type 1 diabetes and occur because the body cannot produce enough insulin to regulate blood sugar levels.

Choice B reason: While weakness, vomiting, hypotension, and mental confusion can be symptoms associated with diabetic ketoacidosis (a serious complication of diabetes), they are not typically the earliest signs of type 1 diabetes. These symptoms may develop later if diabetes is not managed properly.

Choice C reason: Recurrent infections, visual changes, and paresthesia can occur in individuals with diabetes, but they are more common in long-standing diabetes and are not the earliest signs. These symptoms result from chronic high blood sugar levels affecting various body systems.

Choice D reason: Vomiting, abdominal pain, sweet, fruity breath, dehydration, and Kussmaul breathing are symptoms of diabetic ketoacidosis (DKA), a severe and life-threatening complication of diabetes. While these symptoms can occur in individuals with type 1 diabetes, they are not the initial signs but rather indicators of an advanced and poorly controlled condition.