A client presents with bone pain, joint stiffness, and an enlarged skull. Which diagnostic test is most likely to confirm the diagnosis of Paget's disease?
Complete blood count (CBC)
Bone scan
Liver function tests (LFTs)
Magnetic resonance imaging (MRI)
The Correct Answer is B
A bone scan is the most appropriate diagnostic test for confirming the diagnosis of Paget's disease. It can reveal increased bone turnover and abnormal bone remodeling patterns characteristic of the condition. The bone scan can show "hot spots" of increased uptake in affected bones.
a. Complete blood count (CBC): While a CBC can be useful in ruling out other conditions, it does not directly diagnose Paget's disease. Specific bone imaging is required for confirmation.
c. Liver function tests (LFTs): Liver function tests are not used to diagnose Paget's disease. The condition primarily affects bone structures, and liver involvement is not a primary concern.
d. Magnetic resonance imaging (MRI): While an MRI can provide detailed images of bones and soft tissues, it may not be the initial choice for diagnosing Paget's disease. A bone scan is more specific to evaluate bone turnover and remodeling.
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Related Questions
Correct Answer is C
Explanation
The typical clinical manifestations of Paget's disease include bone pain, bone deformities (e.g., enlarged skull, bowed legs), and an increased risk of fractures due to the weakened and structurally abnormal bones. Joint pain and gastrointestinal disturbances are not primary features of Paget's disease.
a. Joint pain and stiffness: Joint pain and stiffness are more characteristic of arthritis or other joint-related conditions, not the primary clinical manifestations of Paget's disease.
b. Muscle weakness and fatigue: While Paget's disease can cause discomfort and reduced mobility, it is not primarily associated with muscle weakness and fatigue.
d. Gastrointestinal disturbances and weight loss: Paget's disease primarily affects bone structures, and gastrointestinal disturbances and weight loss are not typical clinical manifestations of the condition.
Correct Answer is A
Explanation
X-rays are the most useful imaging modality for assessing the extent and severity of bone involvement in Paget's disease. X-rays can reveal the characteristic bony overgrowth and thickening, as well as any bone deformities and fractures.
b. Computed tomography (CT) scan: CT scans can provide detailed images of bones and soft tissues, but they may not be the initial choice for evaluating Paget's disease. X-rays are more specific for the condition.
c. Magnetic resonance imaging (MRI): While an MRI can provide detailed images of bones and soft tissues, it may not be the first-line imaging choice for evaluating Paget's disease. X-rays are more specific for bone involvement.
d. Bone densitometry (DXA scan): Bone densitometry is used to assess bone mineral density and is commonly used for conditions like osteoporosis. It may not provide the necessary information for evaluating Paget's disease.
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