What is the typical pattern of bone involvement in Paget's disease?
Uniform increase in bone density throughout the skeleton.
Focal areas of bone demineralization scattered throughout the skeleton.
Diffuse increase in bone density with areas of focal bone loss.
Patchy areas of increased bone density and disorganized bone formation.
The Correct Answer is D
The typical pattern of bone involvement in Paget's disease is characterized by patchy areas of increased bone density (osteosclerosis) and disorganized bone formation. These areas of abnormal bone remodeling result in structurally weak and misshapen bones.
a. Uniform increase in bone density throughout the skeleton: This pattern of bone density is not characteristic of Paget's disease. The condition involves localized areas of increased density rather than uniform changes.
b. Focal areas of bone demineralization scattered throughout the skeleton: This pattern of bone demineralization is more characteristic of osteoporosis, not Paget's disease.
c. Diffuse increase in bone density with areas of focal bone loss: This pattern is not typical of Paget's disease. The condition primarily involves areas of increased bone density and disordered bone remodeling.
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Correct Answer is C
Explanation
The main difference between Paget's disease and osteoporosis is in the underlying bone remodeling. Paget's disease is characterized by increased bone turnover and disordered bone formation, while osteoporosis involves decreased bone formation and increased bone resorption.
a. Paget's disease is characterized by decreased bone density, while osteoporosis is associated with increased bone density: This statement is incorrect. In Paget's disease, bone density can be normal or increased due to the disordered bone remodeling.
b. Paget's disease primarily affects trabecular bone, while osteoporosis affects cortical bone: This statement is incorrect. Both Paget's disease and osteoporosis can affect both trabecular and cortical bone.
d. Paget's disease is an autoimmune disorder, while osteoporosis is caused by hormonal imbalances: This statement is incorrect. Paget's disease is not an autoimmune disorder, and osteoporosis is not solely caused by hormonal imbalances. Both conditions have complex multifactorial etiologies.
Correct Answer is C
Explanation
The femur, which is the thigh bone, is often affected in Paget's disease. The condition commonly involves the axial skeleton, such as the skull, spine, and pelvis, as well as the long bones like the femur.
a. Humerus (arm bone): The humerus can be affected in Paget's disease, but it is not as commonly involved as the femur.
b. Radius (forearm bone): The radius can be affected in Paget's disease, but it is not as commonly involved as the femur.
d. Fibula (lower leg bone): The fibula can be affected in Paget's disease, but it is not as commonly involved as the femur.
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