What is the typical pattern of bone involvement in Paget's disease?
Uniform increase in bone density throughout the skeleton.
Focal areas of bone demineralization scattered throughout the skeleton.
Diffuse increase in bone density with areas of focal bone loss.
Patchy areas of increased bone density and disorganized bone formation.
The Correct Answer is D
The typical pattern of bone involvement in Paget's disease is characterized by patchy areas of increased bone density (osteosclerosis) and disorganized bone formation. These areas of abnormal bone remodeling result in structurally weak and misshapen bones.
a. Uniform increase in bone density throughout the skeleton: This pattern of bone density is not characteristic of Paget's disease. The condition involves localized areas of increased density rather than uniform changes.
b. Focal areas of bone demineralization scattered throughout the skeleton: This pattern of bone demineralization is more characteristic of osteoporosis, not Paget's disease.
c. Diffuse increase in bone density with areas of focal bone loss: This pattern is not typical of Paget's disease. The condition primarily involves areas of increased bone density and disordered bone remodeling.
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Related Questions
Correct Answer is C
Explanation
The increased bone turnover and remodeling in Paget's disease can cause warmth and erythema (redness) over the affected bones. This is due to the increased blood flow and metabolic activity in the affected areas.
a. Cool, clammy skin: Cool, clammy skin is not directly related to the increased bone turnover and remodeling in Paget's disease. It may be related to other factors, such as circulation or environmental conditions.
b. Pulsating chest pain: Pulsating chest pain is not a typical finding in Paget's disease. It may be related to other cardiac or respiratory conditions.
d. Enlarged skull circumference: An enlarged skull circumference is a common manifestation of Paget's disease, but it is not directly related to the increased bone turnover and remodeling. It results from excessive bone growth in the skull bones.
Correct Answer is C
Explanation
Bisphosphonates are commonly used as the first-line treatment for Paget's disease. They work by slowing down bone resorption and promoting more balanced bone remodeling, helping to control the excessive bone turnover characteristic of the condition.
a. Calcium supplements: While calcium supplements are essential for overall bone health, they are not the first-line treatment for Paget's disease. Bisphosphonates specifically target the abnormal bone remodeling associated with the condition.
b. Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs may help manage pain and inflammation associated with Paget's disease, but they do not directly address the underlying bone remodeling abnormalities. Bisphosphonates are more effective in treating the condition.
d. Vitamin D supplements: Vitamin D is necessary for calcium absorption and bone health, but it is not the primary treatment for Paget's disease. Bisphosphonates are the mainstay of therapy.
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