Which is the treatment of choice for severe aplastic anemia?

A. Insulin is responsible for lowering blood glucose levels by promoting the uptake and storage of glucose in cells.

B. Epinephrine (adrenaline) can raise blood glucose levels in response to the "fight or flight" stress response, but it's not primarily responsible for stimulating liver glycogenolysis.

C. Glucagon is produced by the alpha cells in the islets of Langerhans and plays a crucial role in increasing blood glucose levels. It promotes the breakdown of glycogen (glycogenolysis) in the liver and the production of glucose from non-carbohydrate sources (gluconeogenesis).

D. Adrenocorticotropic hormone (ACTH) is produced by the anterior pituitary gland and stimulates the adrenal cortex to release cortisol, which can also contribute to raising blood glucose levels but isn't primarily responsible for liver glycogenolysis.

In the context of diabetes management, understanding the role of glucagon is important because it helps individuals know how to manage hypoglycemia (low blood sugar) by administering glucagon or consuming fast-acting sources of glucose.

A. Fatigue: Children with ALL often experience fatigue and weakness due to decreased red blood cell and platelet production as a result of bone marrow involvement by leukemia cells.

C. Pallor: Pallor, or paleness, is a common finding in children with ALL because of anemia (reduced red blood cell count).

E. Multiple bruises: Children with ALL may have an increased tendency to bruise and bleed due to low platelet counts, making them susceptible to easy bruising and petechiae.

The other options, B (Generalized edema) and D (Jaundice), are not typical clinical findings associated with ALL. Generalized edema is not a common symptom, and jaundice (yellowing of the skin and eyes) is more commonly associated with liver conditions, not leukemia.