Which is the treatment of choice for severe aplastic anemia?

A. A fontanelle that bulges with crying.

Myelomeningocele is a congenital neural tube defect that involves the spinal cord. It is associated with an increased risk of hydrocephalus, which can lead to increased intracranial pressure (ICP). The fontanelle (soft spot) on an infant's head can provide insight into ICP. When an infant with myelomeningocele has an increase in intracranial pressure, the fontanelle may bulge, especially when the infant cries. This is due to the buildup of cerebrospinal fluid within the skull.

B. Increased respiratory rate: While increased intracranial pressure can affect various body systems, an increased respiratory rate is not a specific sign of ICP associated with myelomeningocele.

C. A high-pitched cry: A high-pitched cry is not typically associated with increased intracranial pressure in the context of myelomeningocele. Signs of ICP in infants may include irritability, lethargy, vomiting, and changes in head circumference.

D. Tachycardia: Tachycardia can be a response to stress or discomfort in an infant, but it is not a specific indicator of increased intracranial pressure related to myelomeningocele.

Option A, "Fatigue," is a symptom of anemia but is not a long-term complication associated with Thalassemia major.

Option B, "Deferoxamine usage," is a treatment to manage iron overload and not a complication associated with Thalassemia major.

Option C, "Immunosuppressive therapy," is not typically used to manage Thalassemia major and is not a long-term complication but rather a potential treatment for certain cases of thalassemia.

Option D. Hemochromatosis/Hemosiderosis

Thalassemia major is a genetic disorder that results in the body's inability to produce enough hemoglobin, leading to severe anemia.

To manage this condition, frequent blood transfusions are required, which can lead to iron overload in the body. Excess iron gets deposited in various organs and tissues, causing damage.

Hemochromatosis or hemosiderosis is a condition characterized by the accumulation of iron in organs like the liver, heart, and endocrine glands, which can result from repeated blood transfusions.

The complications associated with iron overload include liver damage, heart problems, diabetes, and more. Treatment with iron chelating agents like deferoxamine is often necessary to remove excess iron from the body.