Which of the following is a common clinical manifestation of Paget's disease?

An elevated alkaline phosphatase (ALP) level is a common finding in patients with Paget's disease. ALP is an enzyme present in bone cells, and its increased activity is indicative of increased bone turnover and remodeling seen in Paget's disease.

a. Serum calcium level: Serum calcium levels may be affected in Paget's disease due to abnormal bone remodeling, but they are not specific enough to confirm the diagnosis on their own.
b. Erythrocyte sedimentation rate (ESR): The ESR is a marker of inflammation and is not specific to Paget's disease. While it may be elevated due to bone inflammation, it does not confirm the diagnosis.
d. Serum creatinine level: Serum creatinine levels are not directly related to the diagnosis of Paget's disease. They are typically assessed to evaluate kidney function.

Paget's disease can weaken bones, leading to an increased risk of bone fractures. The abnormal bone remodeling and increased bone turnover can result in bones that are more susceptible to breaking.

a. Heart attack: Paget's disease primarily affects bones, not the cardiovascular system. There is no direct association between Paget's disease and an increased risk of heart attacks.

b. Stroke: Paget's disease does not increase the risk of stroke. Stroke is a condition primarily related to the brain and blood vessels, not bones.

c. Osteoporosis: While both Paget's disease and osteoporosis involve changes in bone density, they are distinct conditions. Paget's disease leads to enlarged and weakened bones, while osteoporosis leads to decreased bone density and increased fracture risk.