The nurse is monitoring a client receiving bisphosphonate therapy for Paget's disease. Which laboratory parameter should the nurse prioritize monitoring during treatment?

A. Encouraging high-impact exercises to strengthen bones:
High-impact exercises are contraindicated in patients with Paget's disease due to the risk of fractures and bone injury. Low-impact and weight-bearing exercises are safer to maintain bone health and improve mobility.

B. Monitoring serum calcium levels regularly: Paget's disease often requires treatment with bisphosphonates or calcitonin to regulate bone remodeling. These treatments can affect calcium levels, potentially leading to hypocalcemia. Regular monitoring is crucial to detect and manage these imbalances.

C. Assisting with range-of-motion exercises to maintain joint mobility: While maintaining joint mobility is important, this is not the priority intervention. ROM exercises can be part of the overall care plan but do not address the critical metabolic imbalances associated with Paget's disease.

D. Administering corticosteroids to reduce inflammation: Corticosteroids are not a standard treatment for Paget's disease. Instead, the focus is on medications like bisphosphonates or calcitonin to regulate bone turnover.

A potential complication of Paget's disease is an increased risk of pathologic fractures. The abnormal bone remodeling weakens the bones, leading to an increased susceptibility to fractures.

a. Hypertension: Hypertension is not a direct complication of Paget's disease. The condition primarily affects bone structures.

c. Hyperthyroidism: Hyperthyroidism is not associated with Paget's disease. It is a separate condition related to thyroid gland dysfunction.

d. Type 2 diabetes mellitus: Type 2 diabetes mellitus is not a complication of Paget's disease. The conditions are unrelated and have different underlying causes.