Which of the following medication needs to be taken with 350 calories of food?
clozapine (Clozaril)
aripiprazole (Abilify)
lurasidone (Latuda)
haloperidol (Haldol)
The Correct Answer is C
A. Clozapine (Clozaril) does not require food for absorption, but it has a high risk of sedation, weight gain, and metabolic side effects. It also requires regular blood monitoring due to the risk of agranulocytosis.
B. Aripiprazole (Abilify) can be taken with or without food, as food does not significantly affect its absorption. It is a partial dopamine agonist, associated with a lower risk of weight gain and metabolic issues compared to other atypical antipsychotics.
C. Lurasidone (Latuda) must be taken with at least 350 calories of food to ensure proper absorption. Taking it on an empty stomach reduces its bioavailability, making it less effective. It is considered a weight-neutral antipsychotic and has a lower risk of metabolic side effects.
D. Haloperidol (Haldol) does not require food for absorption. It is a first-generation antipsychotic (FGA) with a high risk of extrapyramidal symptoms (EPS) but minimal metabolic effects.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
A. Mesolimbic pathway is associated with reward, motivation, and emotions and is hyperactive in schizophrenia, leading to positive symptoms such as hallucinations, delusions, and disorganized thinking. Antipsychotic medications work by blocking dopamine (D2) receptors in this pathway, reducing psychotic symptoms.
B. Nigrostriatal pathway controls motor function and coordination. Dopamine blockade in this pathway leads to extrapyramidal symptoms (EPS) such as tremors, rigidity, and tardive dyskinesia, which are common side effects of first-generation antipsychotics (typical antipsychotics).
C. Tuberoinfundibular pathway regulates prolactin secretion. Dopamine inhibits prolactin release, so blocking D2 receptors with antipsychotics leads to increased prolactin levels, causing gynecomastia, galactorrhea, and menstrual irregularities.
D. Mesocortical pathway is responsible for cognition, motivation, and emotional regulation. In schizophrenia, this pathway is hypoactive, contributing to negative symptoms such as apathy, social withdrawal, and cognitive impairment.
Correct Answer is D
Explanation
A. Worry about health despite no symptoms. This describes illness anxiety disorder (formerly hypochondriasis), where individuals have an excessive fear of having a serious illness despite minimal or no physical symptoms. Unlike factitious disorder, these individuals are not fabricating symptoms but are genuinely convinced they are sick.
B. Normal voluntary and sensory dysfunction. This does not describe any recognized psychiatric disorder. However, conversion disorder (functional neurological symptom disorder) involves involuntary neurological symptoms (e.g., paralysis, blindness) without a medical cause, whereas factitious disorder involves intentional symptom fabrication.
C. Worry is out of proportion to the symptoms. This is characteristic of somatic symptom disorder (SSD), where individuals have excessive concern and distress over real but often minor physical symptoms. Unlike factitious disorder, their symptoms are not deliberately produced or exaggerated for attention.
D. Deliberate exaggeration and fabricated symptoms. Factitious disorder (formerly Munchausen syndrome) involves intentionally faking, exaggerating, or inducing medical symptoms to assume the "sick role". Unlike malingering (which is done for external rewards like financial gain), factitious disorder is driven by an internal psychological need for medical attention.
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