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All of the following are first generation antipsychotics except,

A.

clozapine (Clozaril)

B.

haloperidol (Haldol)

C.

fluphenazine (Prolixin)

D.

chlorpromazine (Thorazine)

Answer and Explanation

The Correct Answer is A

A. Clozapine (Clozaril) is a second-generation (atypical) antipsychotic known for its strong dopamine (D2) and serotonin (5-HT2A) blockade. It is primarily used for treatment-resistant schizophrenia but has a high risk of agranulocytosis, metabolic syndrome, and sedation, requiring regular blood monitoring.

B. Haloperidol (Haldol) is a first-generation (typical) antipsychotic that strongly blocks dopamine (D2) receptors, leading to a high risk of extrapyramidal symptoms (EPS) such as dystonia, tardive dyskinesia, and akathisia. It is commonly used for acute psychosis and agitation.

C. Fluphenazine (Prolixin is a first-generation antipsychotic that also strongly antagonizes D2 receptors, making it effective for chronic schizophrenia but highly associated with EPS. It is available in long-acting injectable (LAI) form for maintenance therapy.

D. Chlorpromazine (Thorazine) is a first-generation, low-potency antipsychotic with strong sedative, anticholinergic, and hypotensive effects. While it has a lower risk of EPS compared to high-potency FGAs like haloperidol, it causes more sedation, orthostatic hypotension, and weight gain due to histamine and muscarinic receptor blockade.


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Related Questions

Correct Answer is A

Explanation

A. Vindictive. Being vindictive is more characteristic of oppositional defiant disorder (ODD) rather than conduct disorder (CD). While both disorders involve defiant and hostile behavior, ODD is marked by persistent anger, argumentativeness, and vindictiveness, whereas CD includes more severe violations of social norms and the rights of others.

B. Deceitful. Deceitfulness is a core symptom of conduct disorder. It includes lying, manipulating others, shoplifting, and breaking promises for personal gain. This behavior is often done without guilt or remorse.

C. Aggressive towards people and animals. Physical aggression is a defining feature of conduct disorder. Individuals may bully, threaten, fight, use weapons, or show cruelty towards animals without regard for others' safety.

D. Destroying property. Conduct disorder includes deliberate destruction of property, such as vandalism, arson, or breaking into buildings, often as a way to exert control or express defiance.

Correct Answer is C

Explanation

A. Lurasidone (Latuda) is a second-generation (atypical) antipsychotic, not a third-generation antipsychotic. It primarily blocks dopamine (D2) and serotonin (5-HT2A) receptors and is used to treat schizophrenia and bipolar depression.

B. Cariprazine (Vraylar) is a third-generation antipsychotic, functioning as a partial dopamine (D2/D3) and serotonin (5-HT1A) receptor agonist. It is used for schizophrenia, bipolar disorder, and major depressive disorder (MDD) adjunctive treatment.

C. Haloperidol (Haldol) is a first-generation (typical) antipsychotic, not a third-generation antipsychotic. It works by strongly blocking D2 receptors, leading to a high risk of extrapyramidal symptoms (EPS) but lower metabolic side effects compared to atypical antipsychotics.

D. Aripiprazole (Abilify) is a third-generation antipsychotic, known for its partial dopamine (D2) agonist properties. It has a lower risk of EPS and metabolic side effects compared to second-generation antipsychotics and is used for schizophrenia, bipolar disorder, and adjunctive treatment in depression.

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