All of the following are first generation antipsychotics except,
clozapine (Clozaril)
haloperidol (Haldol)
fluphenazine (Prolixin)
chlorpromazine (Thorazine)
The Correct Answer is A
A. Clozapine (Clozaril) is a second-generation (atypical) antipsychotic known for its strong dopamine (D2) and serotonin (5-HT2A) blockade. It is primarily used for treatment-resistant schizophrenia but has a high risk of agranulocytosis, metabolic syndrome, and sedation, requiring regular blood monitoring.
B. Haloperidol (Haldol) is a first-generation (typical) antipsychotic that strongly blocks dopamine (D2) receptors, leading to a high risk of extrapyramidal symptoms (EPS) such as dystonia, tardive dyskinesia, and akathisia. It is commonly used for acute psychosis and agitation.
C. Fluphenazine (Prolixin is a first-generation antipsychotic that also strongly antagonizes D2 receptors, making it effective for chronic schizophrenia but highly associated with EPS. It is available in long-acting injectable (LAI) form for maintenance therapy.
D. Chlorpromazine (Thorazine) is a first-generation, low-potency antipsychotic with strong sedative, anticholinergic, and hypotensive effects. While it has a lower risk of EPS compared to high-potency FGAs like haloperidol, it causes more sedation, orthostatic hypotension, and weight gain due to histamine and muscarinic receptor blockade.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
A. Restlessness and unable to sit still. This describes akathisia, a movement disorder characterized by an intense feeling of restlessness, often seen as a side effect of antipsychotic medications.
B. Muscle spasms on the face, eyes, neck, and tongue. Dystonia is characterized by sudden, involuntary muscle contractions, often affecting the face, neck (torticollis), eyes (oculogyric crisis), tongue, and jaw. It is a common extrapyramidal side effect (EPS) of antipsychotic medications, particularly first-generation antipsychotics.
C. Tongue rolling and lip smacking. These are hallmark symptoms of tardive dyskinesia, a late-onset movement disorder caused by long-term use of dopamine-blocking agents. It involves involuntary, repetitive movements of the mouth, face, and limbs.
D. Tremors at rest, bradykinesia, and shuffling gait. These symptoms are characteristic of Parkinsonism, an extrapyramidal side effect of dopamine-blocking medications. It mimics Parkinson’s disease and includes rigidity, tremors, and slow movements.
Correct Answer is C
Explanation
A. Believes thoughts are being transmitted to others. This describes thought broadcasting, where individuals believe that their thoughts are being sent to others or that people can hear them without speaking. This is a distinct delusion seen in psychotic disorders like schizophrenia.
B. Believes thoughts are being controlled. This aligns with delusions of control, where a person believes that an external force is controlling their thoughts, feelings, or actions. This is different from thought withdrawal, which specifically involves thoughts being stolen.
C. Believes thoughts are taken out of someone's mind. Thought withdrawal delusions occur when a person believes that an outside force is removing thoughts from their mind. This delusion is common in schizophrenia and other psychotic disorders, often associated with paranoid themes and cognitive disorganization.
D. Believes aliens are inserting thoughts in someone's brain. This describes thought insertion, where individuals believe that outside entities (e.g., aliens, the government) are implanting thoughts into their mind. While related, this differs from thought withdrawal, which involves the removal of thoughts rather than their insertion.
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