Which of the following pathophysiological mechanisms contributes to hyperglycemia in type 2 diabetes mellitus?
Autoimmune destruction of pancreatic beta cells.
Increased sensitivity of cells to insulin.
Insulin resistance in target tissues.
Excess insulin production by the pancreas.
The Correct Answer is C
In type 2 diabetes, insulin resistance occurs, meaning that the body's cells do not respond effectively to the action of insulin. This leads to decreased glucose uptake by cells and elevated blood sugar levels.
Incorrect choices:
a. This choice is incorrect. Autoimmune destruction of pancreatic beta cells is characteristic of type 1 diabetes, not type 2.
b. This choice is incorrect. Increased sensitivity of cells to insulin would result in improved glucose uptake and reduced hyperglycemia.
d. This choice is incorrect. Excess insulin production by the pancreas is not a typical mechanism in type 2 diabetes.
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Correct Answer is D
Explanation
The OGTT measures the body's ability to clear glucose from the blood by drinking a glucose solution and measuring blood glucose levels at specific intervals. It is commonly used to diagnose diabetes mellitus.
Incorrect choices:
a. This choice is incorrect. The fasting blood glucose test measures blood glucose levels after an overnight fast and is not specifically used to assess glucose clearance.
b. This choice is incorrect. The HbA1c test measures average blood glucose levels over the past 2-3 months and is not specifically used to assess glucose clearance.
c. This choice is incorrect. The C-peptide test assesses insulin production by the pancreas and is not specifically used to assess glucose clearance.
Correct Answer is D
Explanation
Long-standing hyperglycemia in diabetes mellitus can lead to impaired wound healing, as high blood sugar levels affect blood flow and immune function, increasing the risk of infections.
Incorrect choices:
a. This choice is incorrect. Polyuria, polydipsia, and polyphagia are the "three P's" associated with diabetes-related hyperglycemia.
b. This choice is incorrect. Nausea, vomiting, and abdominal pain are not typically related to long-standing hyperglycemia in diabetes.
c. This choice is incorrect. Blurred vision and vision loss are manifestations of diabetic retinopathy, a microvascular complication, rather than impaired wound healing.
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