Which of the following pathophysiological mechanisms contributes to hyperglycemia in type 2 diabetes mellitus?
Autoimmune destruction of pancreatic beta cells.
Increased sensitivity of cells to insulin.
Insulin resistance in target tissues.
Excess insulin production by the pancreas.
The Correct Answer is C
In type 2 diabetes, insulin resistance occurs, meaning that the body's cells do not respond effectively to the action of insulin. This leads to decreased glucose uptake by cells and elevated blood sugar levels.
Incorrect choices:
a. This choice is incorrect. Autoimmune destruction of pancreatic beta cells is characteristic of type 1 diabetes, not type 2.
b. This choice is incorrect. Increased sensitivity of cells to insulin would result in improved glucose uptake and reduced hyperglycemia.
d. This choice is incorrect. Excess insulin production by the pancreas is not a typical mechanism in type 2 diabetes.
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Related Questions
Correct Answer is A
Explanation
Type 1 diabetes mellitus is characterized by an autoimmune response that targets and destroys pancreatic beta cells, leading to an absolute deficiency of insulin production.
Incorrect choices:
b. This choice is incorrect. Type 2 diabetes mellitus involves insulin resistance and relative insulin deficiency, but not the autoimmune destruction of beta cells.
c. This choice is incorrect. Gestational diabetes mellitus occurs during pregnancy and is not characterized by autoimmune destruction of beta cells.
d. This choice is incorrect. Secondary diabetes mellitus is caused by other underlying medical conditions or factors and is not primarily characterized by autoimmune destruction of beta cells.
Correct Answer is B
Explanation
A fasting blood glucose level of 100 to 125 mg/dL is considered indicative of prediabetes, which is a condition where blood glucose levels are higher than normal but not high enough to be classified as diabetes.
Incorrect choices:
a. This choice is incorrect. A fasting blood glucose level of 70 mg/dL is within the normal range.
c. This choice is incorrect. A random blood glucose level of 150 mg/dL indicates hyperglycemia, but it is not indicative of prediabetes.
d. This choice is incorrect. An hemoglobin A1c level of 6.5% or higher is diagnostic of diabetes mellitus, not prediabetes.
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