Which of the following pathophysiological mechanisms contributes to hyperglycemia in type 2 diabetes mellitus?
Autoimmune destruction of pancreatic beta cells.
Increased sensitivity of cells to insulin.
Insulin resistance in target tissues.
Excess insulin production by the pancreas.
The Correct Answer is C
In type 2 diabetes, insulin resistance occurs, meaning that the body's cells do not respond effectively to the action of insulin. This leads to decreased glucose uptake by cells and elevated blood sugar levels.
Incorrect choices:
a. This choice is incorrect. Autoimmune destruction of pancreatic beta cells is characteristic of type 1 diabetes, not type 2.
b. This choice is incorrect. Increased sensitivity of cells to insulin would result in improved glucose uptake and reduced hyperglycemia.
d. This choice is incorrect. Excess insulin production by the pancreas is not a typical mechanism in type 2 diabetes.
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Related Questions
Correct Answer is D
Explanation
Chronic hyperglycemia in diabetes mellitus can lead to damage of small blood vessels and nerves, resulting in neuropathy characterized by numbness, tingling, and pain in the extremities.
Incorrect choices:
a. This choice is incorrect. Nausea, vomiting, and abdominal pain are not typically manifestations of neuropathy in diabetes mellitus.
b. This choice is incorrect. Blurred vision and vision loss are associated with diabetic retinopathy, a microvascular complication, not nerve damage.
c. This choice is incorrect. Impaired wound healing and increased susceptibility to infections are related to the effects of hyperglycemia on blood flow and immune function, rather than nerve damage.
Correct Answer is B
Explanation
The "three P's" of diabetes mellitus refer to polyuria (excessive urination), polydipsia (excessive thirst), and polyphagia (excessive hunger) due to the body's inability to effectively use glucose for energy.
Incorrect choices:
a. This choice is incorrect. Increased appetite, weight gain, and bloating are not characteristic of diabetes mellitus; rather, diabetes is associated with weight loss despite increased appetite (polyphagia).
c. This choice is incorrect. Pallor, palpitations, and pain are not specific manifestations of diabetes mellitus.
d. This choice is incorrect. Panic attacks, paranoia, and paresthesia are not typical clinical manifestations of diabetes mellitus.
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