Which of the following responses indicate that the nurse understands the first-pass effect?
Medication routes that are affected by the first-pass effect include intravenous, intramuscular, and intradermal.
Enteric-coated tablets and capsules are affected by the first-pass effect except a pharmacologic effect.
The first-pass effect is when the liver activates all medications on their first pass through the liver.
Enteral medications may need a higher dose due to the first-pass effect.
The Correct Answer is D
Choice A rationale
Intravenous, intramuscular, and intradermal routes bypass the first-pass effect as they do not pass through the liver first.
Choice B rationale
Enteric-coated tablets and capsules are designed to bypass the stomach and dissolve in the intestines, reducing the first-pass effect.
Choice C rationale
The first-pass effect involves the liver metabolizing and inactivating a portion of the medication on its first pass through the liver.
Choice D rationale
Enteral medications, which pass through the digestive system, may require higher doses due to the first-pass effect where the liver metabolizes the medication before it reaches systemic circulation. .
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A rationale
Waiting at least 5 minutes between puffs allows the first dose to take effect, optimizing absorption and reducing side effects when different inhaled medications are used.
Choice B rationale
Waiting 10 minutes between puffs is unnecessary and might reduce adherence to treatment due to the prolonged interval.
Choice C rationale
"None of the above" does not provide a valid education point for using metered-dose inhalers.
Choice D rationale
"All of the above" is incorrect as it includes a recommendation that is not necessary (waiting 10 minutes). .
Correct Answer is D
Explanation
Choice A rationale
Tumor enhancer genes is not a recognized term in oncology. DNA repair genes, along with proto-oncogenes and tumor suppressor genes, are critical in cancer development.
Choice B rationale
There are specific genes involved in cancer development, as mentioned in the other options.
Choice C rationale
Proto-oncogenes and tumor suppressor genes are both involved, but DNA repair genes also play a significant role.
Choice D rationale
Proto-oncogenes, tumor suppressor genes, and DNA repair genes collectively contribute to cancer development by either promoting or failing to prevent cell proliferation and damage repair.
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