A nurse is preparing to educate a patient who has newly been prescribed sucralfate (Carafate) for the management of peptic ulcer disease (PUD). What is the mechanism of action for this medication?
Neutralizes the acidity of the gastric acid.
Acts as an endogenous prostaglandin in the GI tract.
Antagonizes H2 receptors on parietal cells.
Creates a protective barrier that adheres to an ulcer, which can stick to the ulcer for up to 6 hours.
The Correct Answer is D
A. Sucralfate does not neutralize gastric acid; antacids are responsible for neutralization.
B. Sucralfate does not mimic endogenous prostaglandins. Medications like misoprostol act as prostaglandins to protect the stomach lining.
C. Sucralfate does not block H2 receptors. Medications like cimetidine or ranitidine work through this mechanism to reduce acid production.
D. Sucralfate creates a viscous, protective barrier that adheres to the ulcer site, shielding it from further damage by gastric acid, bile, and pepsin for up to 6 hours, thereby promoting healing.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["A","D"]
Explanation
A. Long-term use of omeprazole is associated with an increased risk of osteoporosis and fractures due to decreased calcium absorption caused by reduced stomach acid. This complication is significant in older adults, particularly with prolonged therapy.
B. Torsades de Pointes is not a common complication of omeprazole. QT prolongation is more often linked to medications like ondansetron or antiarrhythmics.
C. Nausea is not a typical complication of omeprazole; rather, it is a symptom the drug may help alleviate as part of managing gastrointestinal conditions.
D. Rebound acid hypersecretion can occur after discontinuation of omeprazole. The body may produce an excessive amount of acid to compensate for the previous suppression, leading to worsening symptoms if the medication is abruptly stopped.
Correct Answer is A
Explanation
A. Hyperglycemia: While metformin is used to manage blood glucose levels in clients with diabetes, its interaction with contrast dye does not directly lead to hyperglycemia. However, the risk for kidney injury, which can affect glucose regulation, is a concern.
B. Acute renal failure: This is correct. The combination of metformin and iodine-containing contrast dye increases the risk of acute renal failure, also known as contrast-induced nephropathy (CIN). This occurs because contrast agents can cause kidney damage, and metformin is excreted by the kidneys. If renal function is impaired, the buildup of metformin can lead to lactic acidosis.
C. Acute pancreatitis: While acute pancreatitis is a possible side effect of metformin in some individuals, the primary concern with iodine-containing contrast dye is renal failure, not pancreatitis.
D. Acute liver failure: Metformin is primarily metabolized by the kidneys, not the liver, and does not commonly cause liver failure. Renal failure is the more pressing concern with the use of contrast dye in clients taking metformin.
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