Which type of hemolytic anemia is categorized as an inherited disorder?
Sickle cell anemia
Hypersplenism
Cold agglutinin disease
Autoimmune hemolytic anemia
The Correct Answer is A
Reasoning:
Choice A reason: Sickle cell anemia is an inherited disorder caused by a genetic mutation in the hemoglobin gene, leading to abnormal hemoglobin (HbS). This causes red blood cells to sickle under stress, triggering hemolysis. The autosomal recessive inheritance pattern makes it a classic example of an inherited hemolytic anemia with chronic hemolysis.
Choice B reason: Hypersplenism is not an inherited disorder but a condition where an enlarged spleen sequesters and destroys red blood cells, causing anemia. It results from secondary causes like liver disease or portal hypertension, not genetic mutations, making it an acquired cause of hemolytic anemia.
Choice C reason: Cold agglutinin disease is typically acquired, often due to infections or autoimmune disorders, causing antibodies to agglutinate red blood cells at low temperatures, leading to hemolysis. While rare congenital forms exist, it is not primarily inherited, unlike sickle cell anemia’s genetic basis.
Choice D reason: Autoimmune hemolytic anemia is usually acquired, caused by autoantibodies attacking red blood cells, leading to hemolysis. It is associated with conditions like lupus or infections, not genetic mutations. Unlike sickle cell anemia, it lacks an inherited genetic component as its primary etiology.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Reasoning:
Choice A reason: Palpating lymph nodes and tonsils is relevant for assessing infections or malignancies but is not a primary intervention for thrombocytopenia. Corticosteroids treat thrombocytopenia by suppressing autoimmune platelet destruction, and the focus is on bleeding prevention, not lymphoid assessment, which is secondary to managing low platelet counts.
Choice B reason: Eliminating aspirin and NSAIDs is critical in thrombocytopenia, as these drugs inhibit platelet function, increasing bleeding risk in patients with low platelet counts. Corticosteroids improve platelet production, but concurrent use of antiplatelet drugs could exacerbate bleeding tendencies, making their elimination a primary nursing intervention.
Choice C reason: Gradually tapering corticosteroids is important to prevent adrenal suppression but is not the primary intervention during initial therapy for thrombocytopenia. The immediate focus is on preventing bleeding complications due to low platelets, with tapering being a later consideration once platelet counts stabilize.
Choice D reason: Examining extremities for redness may detect infection or inflammation but is not the primary intervention for thrombocytopenia. Bleeding risk from low platelets is the main concern, and while redness could indicate complications, eliminating drugs that impair platelet function is more critical to prevent hemorrhage.
Correct Answer is B
Explanation
Reasoning:
Choice A reason: Pale thick skin is not a typical effect of long-term corticosteroid use. Corticosteroids cause skin thinning due to reduced collagen production, leading to fragile, atrophic skin prone to bruising. Thick skin is more associated with conditions like scleroderma, not the catabolic effects of corticosteroids on skin tissue.
Choice B reason: Moon face is a classic sign of long-term corticosteroid use, resulting from fat redistribution to the face due to glucocorticoid-induced lipolysis and lipogenesis. Excess cortisol promotes fat deposition in the face and trunk, creating a rounded facial appearance, a hallmark of Cushing syndrome or iatrogenic corticosteroid effects.
Choice C reason: Weight loss is not expected with long-term corticosteroid use. Corticosteroids increase appetite and promote fat redistribution, leading to weight gain, particularly in the trunk and face. Weight loss may occur in conditions like Addison’s disease, where cortisol is deficient, not in hypercortisolism states.
Choice D reason: Hypotension is not a common effect of corticosteroids. They can cause fluid retention and increased blood volume due to mineralocorticoid activity, potentially leading to hypertension. Hypotension is more associated with adrenal insufficiency, where cortisol and aldosterone deficiencies reduce vascular tone and fluid balance.
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