Why is glucose metabolism profoundly affected during pregnancy?

The pregnant woman uses glucose at a more rapid rate than the nonpregnant woman.

Placental hormones are antagonistic to insulin, thus resulting in insulin resistance.

Pancreatic function in the islets of Langerhans is affected by pregnancy.

The pregnant woman increases her dietary intake significantly.

Answer and Explanation

The Correct Answer is B

Choice A reason: This is not the correct answer, as the pregnant woman does not use glucose at a more rapid rate than the nonpregnant woman. In fact, the pregnant woman has lower fasting glucose levels and higher postprandial glucose levels than the nonpregnant woman. This is because the pregnant woman adapts to the increased fetal demand for glucose by increasing her insulin secretion and decreasing her hepatic glucose production.

Choice B reason: This is the correct answer, as placental hormones are antagonistic to insulin, thus resulting in insulin resistance. Insulin resistance is a condition where the cells do not respond well to insulin and require more insulin to maintain normal glucose levels. Placental hormones, such as human placental lactogen, progesterone, and cortisol, increase the insulin resistance of the maternal tissues, especially in the second and third trimesters of pregnancy. This is to ensure that the fetus has enough glucose supply, as the placenta is not insulin resistant and can transport glucose to the fetus².

Choice C reason: This is not the correct answer, as pancreatic function in the islets of Langerhans is not affected by pregnancy. The islets of Langerhans are clusters of cells in the pancreas that produce hormones, such as insulin and glucagon, that regulate glucose metabolism. Pregnancy does not impair the function of the islets of Langerhans, but rather stimulates them to increase their size and number. This is to compensate for the increased insulin resistance and glucose demand of the pregnancy.

Choice D reason: This is not the correct answer, as the pregnant woman does not increase her dietary intake significantly. The pregnant woman needs to consume adequate calories and nutrients to support the fetal growth and development, but not excessively. The recommended weight gain during pregnancy depends on the pre-pregnancy BMI of the woman, but generally ranges from 11 to 16 kg. The recommended calorie intake during pregnancy is about 300 kcal more than the pre-pregnancy intake, which is equivalent to one extra snack per day.

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Correct Answer is A

Explanation

Choice A reason: A previous birth of a large infant (macrosomia) is a risk factor for gestational diabetes mellitus (GDM). A large infant may indicate that the mother had high blood glucose levels during pregnancy, which can cause the fetus to grow larger than normal. Women who have had a large infant are more likely to develop GDM in subsequent pregnancies.

Choice B reason: Underweight before pregnancy is not a risk factor for GDM. In fact, being overweight or obese before pregnancy is a risk factor for GDM, as it increases insulin resistance and makes it harder for the body to use glucose effectively.

Choice C reason: A previous diagnosis of type 2 diabetes mellitus is not a risk factor for GDM. It is a contraindication for GDM, as it means that the woman already has diabetes before pregnancy. GDM is a condition that develops during pregnancy and usually resolves after delivery.

Choice D reason: Maternal age younger than 25 years is not a risk factor for GDM. In fact, being older than 25 years is a risk factor for GDM, as it increases the risk of insulin resistance and other metabolic changes that can affect glucose tolerance.

A. Eat five small meals daily. B. Lie down after each meal. C. Reduce the amount of fiber she consumes. D. Substitute other calcium sources for milk in her diet.

Correct Answer is A

Explanation

Choice A reason: Eating five small meals daily can help reduce heartburn in pregnancy by preventing overeating and reducing the pressure on the stomach from the growing uterus. It can also help maintain a steady blood glucose level and prevent nausea and vomiting.

Choice B reason: Lying down after each meal can worsen heartburn in pregnancy by allowing the stomach acid to reflux into the esophagus. It can also cause breathing difficulties and increase the risk of aspiration. The woman should avoid lying down for at least two hours after eating and elevate her head and chest when sleeping.

Choice C reason: Reducing the amount of fiber she consumes can cause constipation and hemorrhoids in pregnancy, which can increase the discomfort and pain. Fiber is important for maintaining a healthy digestive system and preventing gestational diabetes and preeclampsia. The woman should consume at least 25 grams of fiber per day from fruits, vegetables, whole grains, beans, and nuts.

Choice D reason: Substituting other calcium sources for milk in her diet can deprive the woman and the baby of essential nutrients, such as protein, vitamin D, and riboflavin. Milk is not a common cause of heartburn in pregnancy, unless the woman is lactose intolerant or allergic to dairy products. The woman should consume at least three servings of dairy products per day or take calcium supplements as prescribed.

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Why is glucose metabolism profoundly affected during pregnancy?

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Naxlex Comprehensive Predictor Exams

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Correct Answer is A

Explanation

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Correct Answer is A

Explanation

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