A client asks the nurse why she needs to increase her fluid intake while taking sulfonamides.
Which response by the nurse would be most appropriate?

Choice A rationale:

Antiviral drugs are metabolized in the liver, and hepatic impairment can affect the metabolism and elimination of these drugs. Therefore, the nurse should administer antiviral therapy cautiously to clients with hepatic impairment to prevent potential drug toxicity. Hepatic impairment can alter the pharmacokinetics of antiviral drugs, leading to increased drug levels in the bloodstream.

Choice B rationale:

Renal impairment is not typically a contraindication for antiviral therapy. While some medications may require dose adjustments in patients with renal impairment, it is not a general concern for antiviral drugs. The primary organ responsible for the metabolism of antiviral drugs is the liver.

Choice C rationale:

Diabetes and hypertension are chronic medical conditions that are not directly related to the administration of antiviral therapy. These conditions do not significantly impact the pharmacokinetics or pharmacodynamics of antiviral drugs. Therefore, they are not primary factors to consider when administering antiviral therapy.

Choice D rationale:

Hypertension, like diabetes, is not directly related to the administration of antiviral therapy. Antiviral drugs primarily interact with the liver's metabolic pathways, and hypertension does not have a significant impact on drug metabolism.

Choice A rationale:

Simethicone is not typically associated with causing heartburn. Its primary function is to relieve gas in the digestive system and alleviate abdominal discomfort.

Choice B rationale:

Simethicone is not known to induce vomiting. It is used to reduce gas in the gastrointestinal tract, and its side effects are generally mild.

Choice C rationale:

Fainting is not a common side effect of simethicone. Simethicone is generally well-tolerated and does not have a significant impact on blood pressure or consciousness.

Choice D rationale:

The nurse should assess the client for the possibility of nausea after administering simethicone. Nausea is a potential side effect of the medication, although it is not very common. Monitoring for this side effect is important to ensure the client's comfort and safety.